R GIGG
Overview
Explore the profile of R GIGG including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
433
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0
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Recent Articles
1.
Salim K, Bottomley M, Querfurth E, Zvelebil M, Gout I, Scaife R, et al.
EMBO J
. 1996 Nov;
15(22):6241-50.
PMID: 8947047
Pleckstrin homology (PH) domains may act as membrane localization modules through specific interactions with phosphoinositide phospholipids. These interactions could represent responses to second messengers, with scope for regulation by soluble...
2.
James S, Downes C, GIGG R, Grove S, Holmes A, Alessi D
Biochem J
. 1996 May;
315 ( Pt 3):709-13.
PMID: 8645147
Recent evidence has suggested that activation of phosphoinositide 3-kinase (PI 3-kinase) is required for the activation of Akt-1 by growth factors and insulin. Here we demonstrate by two independent methods...
3.
Desai T, Gigg J, GIGG R
Carbohydr Res
. 1996 Jan;
280(2):209-21.
PMID: 8593636
D-Ribose was converted into methyl 5-O-benzyl-beta-D-ribofuranoside and this, on tin-mediated allylation, gave a mixture of the 2-O-allyl and 3-O-allyl derivatives which were separated by chromatography. The more polar isomer was...
4.
Palmer R, Dekker L, Woscholski R, Le Good J, GIGG R, Parker P
J Biol Chem
. 1995 Sep;
270(38):22412-6.
PMID: 7673228
As potential targets for polyphosphoinositides, activation of protein kinase C (PKC) isotypes (beta 1, epsilon, zeta, nu) and a member of the PKC-related kinase (PRK) family, PRK1, has been compared...
5.
Wilcox R, Erneux C, Primrose W, GIGG R, Nahorski S
Biochem Soc Trans
. 1995 Aug;
23(3):420S.
PMID: 8566308
No abstract available.
6.
Wilcox R, Erneux C, Primrose W, GIGG R, Nahorski S
Mol Pharmacol
. 1995 Jun;
47(6):1204-11.
PMID: 7603461
The novel, synthetic, adenophostin A analogue 2-hydroxyethyl-alpha-D-glucopyranoside-2,3',4'-trisphosphate [Glu(2,3',4')P3] was synthesized to probe the structure-activity relationship at the D-myo-inositol-1,4,5-trisphosphate [Ins(1,4,5)P3] receptor [Ins(1,4,5)P3R]. This study was stimulated by the recent observation that...
7.
Desai T, Gigg J, GIGG R
Carbohydr Res
. 1994 Sep;
262(1):59-77.
PMID: 7954520
The preparation of 1D-1,6-di-O-benzyl-2,5-di-O-p-methoxybenzyl-myo-inositol is described. This compound and 1D-3,6-di-O-benzyl-1,2-O-isopropylidene-myo-inositol were converted into 1D-1,3,6-tri-O-benzyl-myo-inositol which was phosphorylated to give an intermediate for the synthesis of 1D-myo-inositol 2,4,5-trisphosphate. 1D-3,6-Di-O-benzyl-1,2-O-isopropylidene-myo-inositol was converted...
8.
Abdullah M, Hughes P, Craxton A, GIGG R, Desai T, Marecek J, et al.
J Biol Chem
. 1992 Nov;
267(31):22340-5.
PMID: 1331051
The metabolism of inositol 1,3,4-trisphosphate is a pivotal branch point of inositol phosphate turnover; its dephosphorylation replenishes cellular inositol pools, its phosphorylation at the 6-position supports the synthesis of inositol...
9.
Desai T, Gigg J, GIGG R, Payne S, Penades S
Carbohydr Res
. 1992 Oct;
234:1-21.
PMID: 1468077
Racemic 1,2,4-tri-O-benzyl-5,6-O-isopropylidene-myo-inositol was prepared by a new route involving crotyl (but-2-enyl) ethers and converted into the (-)-omega-camphanates to give the pure crystalline 1L-diastereoisomer and the chirally impure, syrupy 1D-diastereoisomer. The...
10.