R F Loeser
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Explore the profile of R F Loeser including associated specialties, affiliations and a list of published articles.
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69
Citations
2265
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Recent Articles
1.
Cui Y, Miao M, Wang M, Su Q, Qiu K, Arbeeva L, et al.
Osteoarthritis Cartilage
. 2023 Apr;
31(8):1078-1090.
PMID: 37100374
Objective: Yes-associated protein (YAP) has been widely studied as a mechanotransducer in many cell types, but its function in cartilage is controversial. The aim of this study was to identify...
2.
Rushing B, McRitchie S, Arbeeva L, Nelson A, Azcarate-Peril M, Li Y, et al.
Osteoarthritis Cartilage
. 2021 Oct;
30(1):81-91.
PMID: 34718137
Objective: The objective of this exploratory study was to determine if perturbations in gut microbial composition and the gut metabolome could be linked to individuals with obesity and osteoarthritis (OA)....
3.
Flannery C, Seaman S, Buddin K, Nasert M, Semler E, Kelley K, et al.
Osteoarthritis Cartilage
. 2021 May;
29(8):1203-1212.
PMID: 34023528
Objective: Characterization of a novel human placental tissue-derived biologic, PTP-001, which is in development as a candidate therapeutic for the treatment of osteoarthritis symptoms and pathophysiology. Methods: Human placental tissues...
4.
Armstrong A, Carlson C, Rendahl A, Loeser R
Osteoarthritis Cartilage
. 2021 Feb;
29(4):536-546.
PMID: 33561541
Objective: To compare the Osteoarthritis Research Society International (OARSI) and Articular Cartilage Structure (ACS) grading schemes applied to multiple and single sections, along with additional histologic measures, in two mouse...
5.
Reed K, Ulici V, Kim C, Chubinskaya S, Loeser R, Phanstiel D
Osteoarthritis Cartilage
. 2020 Nov;
29(2):235-247.
PMID: 33248223
Objective: Fibronectin is a matrix protein that is fragmented during cartilage degradation in osteoarthritis (OA). Treatment of chondrocytes with fibronectin fragments (FN-f) has been used to model OA in vitro,...
6.
Copp M, Flanders M, Gagliardi R, Gilbertie J, Sessions G, Chubinskaya S, et al.
Osteoarthritis Cartilage
. 2020 Nov;
29(3):402-412.
PMID: 33227437
Objective: Cellular senescence is a phenotypic state characterized by stable cell-cycle arrest, enhanced lysosomal activity, and the secretion of inflammatory molecules and matrix degrading enzymes. Senescence has been implicated in...
7.
van Spil W, Bierma-Zeinstra S, Deveza L, Arden N, Bay-Jensen A, Kraus V, et al.
Arthritis Res Ther
. 2020 Mar;
22(1):54.
PMID: 32192519
Background: The concept of osteoarthritis (OA) heterogeneity is evolving and gaining renewed interest. According to this concept, distinct subtypes of OA need to be defined that will likely require recognition...
8.
Munugoda I, Beavers D, Wirth W, Aitken D, Loeser R, Miller G, et al.
Osteoarthritis Cartilage
. 2020 Feb;
28(4):410-417.
PMID: 32014493
Objective: Weight loss has beneficial effects on clinical outcomes in knee osteoarthritis (OA), but the mechanism is still unclear. Since meniscus extrusion is associated with knee pain, this study assessed...
9.
Runhaar J, Beavers D, Miller G, Nicklas B, Loeser R, Bierma-Zeinstra S, et al.
Osteoarthritis Cartilage
. 2019 Apr;
27(8):1118-1123.
PMID: 31009749
Objective: Diet restriction and exercise form key treatments for osteoarthritis (OA) related symptoms in overweight and obese individuals. Although both interventions are known to influence systemic low-grade inflammation, which is...
10.
Nelson A, Fang F, Arbeeva L, Cleveland R, Schwartz T, Callahan L, et al.
Osteoarthritis Cartilage
. 2019 Apr;
27(7):994-1001.
PMID: 31002938
Objective: Knee osteoarthritis (KOA) is a heterogeneous condition representing a variety of potentially distinct phenotypes. The purpose of this study was to apply innovative machine learning approaches to KOA phenotyping...