R F Loeser
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Explore the profile of R F Loeser including associated specialties, affiliations and a list of published articles.
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69
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2265
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Recent Articles
11.
Collins J, Arbeeva L, Chubinskaya S, Loeser R
Osteoarthritis Cartilage
. 2018 Dec;
27(4):703-711.
PMID: 30590195
Objective: To compare key intracellular redox-regulated signaling pathways in chondrocytes derived from knee joint femoral cartilage and ankle joint talar cartilage in order to determine if differences exist that might...
12.
Ulici V, Kelley K, Azcarate-Peril M, Cleveland R, Sartor R, Schwartz T, et al.
Osteoarthritis Cartilage
. 2018 Jun;
26(8):1098-1109.
PMID: 29857156
Objective: To determine the contribution of the gut microbiota to the development of injury-induced osteoarthritis (OA). Design: OA was induced using the destabilized medial meniscus (DMM) model in 20 germ-free...
13.
Noehren B, Kosmac K, Walton R, Murach K, Lyles M, Loeser R, et al.
Osteoarthritis Cartilage
. 2018 May;
26(10):1359-1368.
PMID: 29800621
Objective: Quadriceps muscle weakness is common in knee osteoarthritis (OA). While pain, disuse, and atrophy are commonly cited causes for muscle weakness in OA, emerging evidence suggests changes in muscle...
14.
Loeser R, Beavers D, Bay-Jensen A, Karsdal M, Nicklas B, Guermazi A, et al.
Osteoarthritis Cartilage
. 2017 Jul;
25(11):1822-1828.
PMID: 28756278
Objective: To examine the effects of dietary weight loss, with and without exercise, on selected soluble biomarkers in overweight and obese older adults with symptomatic knee osteoarthritis (OA). Design: Blood...
15.
Huang G, Chubinskaya S, Liao W, Loeser R
Osteoarthritis Cartilage
. 2017 Jun;
25(9):1505-1515.
PMID: 28587781
Objective: Aberrant Wnt signaling may contribute to osteoarthritis (OA) but the Wnt family members involved have not been fully identified. The purpose of this study was to investigate the role...
16.
Nazli S, Loeser R, Chubinskaya S, Willey J, Yammani R
Osteoarthritis Cartilage
. 2017 May;
25(9):1516-1521.
PMID: 28545881
Introduction: Insulin-like growth factor-1 (IGF-1) promotes matrix synthesis and cell survival in cartilage. Chondrocytes from aged and osteoarthritic cartilage have a reduced response to IGF-1. The purpose of this study...
17.
Longobardi L, Temple J, Tagliafierro L, Willcockson H, Esposito A, DOnofrio N, et al.
Osteoarthritis Cartilage
. 2016 Nov;
25(6):914-925.
PMID: 27856294
Objective: We previously found in our embryonic studies that proper regulation of the chemokine CCL12 through its sole receptor CCR2, is critical for joint and growth plate development. In the...
18.
Loeser R, Pathmasiri W, Sumner S, McRitchie S, Beavers D, Saxena P, et al.
Osteoarthritis Cartilage
. 2016 Mar;
24(8):1479-86.
PMID: 27012755
Introduction: Metabolic factors may contribute to osteoarthritis (OA). This study employed metabolomics analyses to determine if differences in metabolite profiles could distinguish people with knee OA who exhibited radiographic progression....
19.
Vanderman K, Loeser R, Chubinskaya S, Anderson A, Ferguson C
Osteoarthritis Cartilage
. 2016 Jan;
24(6):1036-46.
PMID: 26778533
Objective: Many cell types lose responsiveness to anabolic factors during inflammation and disease. Osteogenic Protein 1 (OP1/BMP7) was evaluated for the ability to enhance extracellular matrix synthesis in healthy and...
20.
Greene M, Loeser R
Osteoarthritis Cartilage
. 2015 Nov;
23(11):1966-71.
PMID: 26521742
It is well accepted that aging is an important contributing factor to the development of osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may include an age-related pro-inflammatory...