R F Castilho
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Explore the profile of R F Castilho including associated specialties, affiliations and a list of published articles.
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44
Citations
1196
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Recent Articles
1.
Mirandola S, Melo D, Schuck P, Ferreira G, Wajner M, Castilho R
J Inherit Metab Dis
. 2008 Jan;
31(1):44-54.
PMID: 18213522
The effect of methylmalonate (MMA) on mitochondrial succinate oxidation has received great attention since it could present an important role in energy metabolism impairment in methylmalonic acidaemia. In the present...
2.
Santos N, Castilho R, Meinicke A, Hermes-Lima M
Eur J Pharmacol
. 2002 Jan;
428(1):37-44.
PMID: 11779035
Pyridoxal isonicotinoyl hydrazone (PIH) is able to prevent iron-mediated hydroxyl radical formation by means of iron chelation and inhibition of redox cycling of the metal. In this study, we investigated...
3.
Maciel E, Vercesi A, Castilho R
J Neurochem
. 2001 Dec;
79(6):1237-45.
PMID: 11752064
Mitochondrial permeability transition (PT) is a non-selective inner membrane permeabilization, typically promoted by the accumulation of excessive quantities of Ca(2+) ions in the mitochondrial matrix. This phenomenon may contribute to...
4.
Hansson O, Guatteo E, Mercuri N, Bernardi G, Li X, Castilho R, et al.
Eur J Neurosci
. 2001 Nov;
14(9):1492-504.
PMID: 11722611
Transgenic Huntington's disease (HD) mice, expressing exon 1 of the human HD gene (lines R6/1 and R6/2), are totally resistant to striatal lesions caused by the NMDA receptor agonist quinolinic...
5.
Petersen A, Hansson O, Puschban Z, Sapp E, Romero N, Castilho R, et al.
Eur J Neurosci
. 2001 Nov;
14(9):1425-35.
PMID: 11722604
Huntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease....
6.
Bernardes C, Fagian M, Meyer-Fernandes J, Castilho R, Vercesi A
Toxicology
. 2001 Nov;
169(1):17-23.
PMID: 11696406
Suramin, a polysulfonated naphthylamine, caused a dose dependent inhibition of carbonyl cyanide p-(tri-fluoromethoxy)phenylhydrazone-stimulated respiration supported either by succinate or a cocktail of alphaketoglutarate, malate and isocitrate in isolated rat liver...
7.
Hansson O, Castilho R, Korhonen L, Lindholm D, Bates G, Brundin P
J Neurochem
. 2001 Aug;
78(4):694-703.
PMID: 11520890
Transgenic Huntington's disease (HD) mice, expressing exon 1 of the HD gene with an expanded CAG repeat, are totally resistant to striatal lesion induced by excessive NMDA receptor activation. We...
8.
Fortes F, Castilho R, Catisti R, Carnieri E, Vercesi A
J Bioenerg Biomembr
. 2001 Jul;
33(1):43-51.
PMID: 11460925
Oxidative damage of mammalian mitochondria induced by Ca2+ and prooxidants is mediated by the attack of mitochondria-generated reactive oxygen species on membrane protein thiols promoting oxidation and cross-linkage that leads...
9.
Kowaltowski A, Castilho R, Vercesi A
FEBS Lett
. 2001 Apr;
495(1-2):12-5.
PMID: 11322939
Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known...
10.
Improving the survival of grafted embryonic dopamine neurons in rodent models of Parkinson's disease
Castilho R, Hansson O, Brundin P
Prog Brain Res
. 2001 Jan;
127:203-31.
PMID: 11142029
No abstract available.