R E West Jr
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Explore the profile of R E West Jr including associated specialties, affiliations and a list of published articles.
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20
Citations
280
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Recent Articles
1.
Morse K, Behan J, Laz T, West Jr R, Greenfeder S, Anthes J, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(3):1058-66.
PMID: 11181941
Histamine exerts its numerous physiological functions through interaction with G protein-coupled receptors. Three such receptors have been defined at both the pharmacological and molecular level, while pharmacological evidence hints at...
2.
West Jr R, Wu R, Billah M, Egan R, Anthes J
Eur J Pharmacol
. 1999 Aug;
377(2-3):233-9.
PMID: 10456436
Characterization of the histamine H3 receptor in rodent species has been extensive but limited characterization has been done with primate or human tissue. We have characterized the binding of [3H]Nalpha-methylhistamine...
3.
Piwinski J, Wong J, Green M, Kaminski J, Colizzo F, Albanese M, et al.
Bioorg Med Chem Lett
. 1999 Feb;
8(24):3469-74.
PMID: 9934454
A series of N-acyl-4-(5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin- 11-ylidene)piperazines is described that are dual antagonists of PAF and histamine. The structural requirements for activity in this series parallel those of their previously reported piperidinylidene...
4.
Carruthers N, Spitler J, Wong S, Blythin D, Chen X, Shue H, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(21):3059-64.
PMID: 9873676
A series of gamma-aminobutyric acid (GABA) 1 analogs was prepared in which the carboxylic acid group of GABA was replaced with a sulfinic acid group and their affinity for the...
5.
Wolin R, Connolly M, Afonso A, Hey J, She H, Rivelli M, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(16):2157-62.
PMID: 9873505
Sulfonamides derived from 4(5)-(omega-aminoalkyl)-1H-imidazoles containing chain lengths of three- to five-carbons were synthesized. Good to moderate H3 receptor binding affinities were observed for several butyl and pentyl homologs, whereas binding...
6.
West Jr R, Williams S, She H, Carruthers N, Egan R, Billah M
Prostaglandins
. 1998 Apr;
54(6):891-8.
PMID: 9533184
Tomoxiprole is a nonsteroidal anti-inflammatory compound that was reported to have low ulcerogenic potential, a quality that would be expected of a cyclooxygenase-2-selective inhibitor, and, in fact, we find it...
7.
West Jr R, Myers J, Zweig A, Siegel M, Egan R, Clark M
Eur J Pharmacol
. 1994 May;
267(3):343-8.
PMID: 8088374
Histamine H3 receptors have been identified in rat and guinea-pig pituitary glands and in the mouse pituitary tumor cell line, AtT-20. Histamine H3 receptor agonists are reported to stimulate adrenocorticotropic...
8.
Zweig A, Siegel M, Egan R, Clark M, Shorr R, West Jr R
J Neurochem
. 1992 Nov;
59(5):1661-6.
PMID: 1328529
The H3 receptor is a high-affinity histamine receptor that inhibits release of several neurotransmitters, including histamine. We have characterized H3 receptor binding in bovine brain and developed conditions for its...
9.
Piwinski J, Wong J, Green M, Ganguly A, Billah M, West Jr R, et al.
J Med Chem
. 1991 Jan;
34(1):457-61.
PMID: 1671420
No abstract available.
10.
West Jr R, Zweig A, Granzow R, Siegel M, Egan R
J Neurochem
. 1990 Nov;
55(5):1612-6.
PMID: 2213013
The H3 histamine receptor is a high-affinity receptor reported to mediate inhibition of CNS histidine decarboxylase activity and depolarization-induced histamine release. We have used (R)-alpha-[3H]methylhistamine, a specific, high-affinity agonist, to...