R de Waal Malefyt
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Explore the profile of R de Waal Malefyt including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Rissoan M, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R, et al.
Science
. 1999 Feb;
283(5405):1183-6.
PMID: 10024247
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic...
12.
Teunissen M, Koomen C, de Waal Malefyt R, Wierenga E, Bos J
J Invest Dermatol
. 1998 Oct;
111(4):645-9.
PMID: 9764847
Keratinocytes are influenced by cytokines released by skin-infiltrating T lymphocytes. IL-17 is produced by activated CD4+ T cells and can stimulate epithelial cells. We investigated whether IL-17 could modulate the...
13.
Zipp F, Kerschensteiner M, Dornmair K, Malotka J, Schmidt S, Bender A, et al.
Brain
. 1998 Aug;
121 ( Pt 8):1395-407.
PMID: 9712003
More precise understanding of the immune response against T-cell receptors (TCRs) is a prerequisite for successful TCR vaccination therapy of multiple sclerosis and other neurological autoimmune diseases. We conducted a...
14.
Subauste C, Fuh F, de Waal Malefyt R, Remington J
J Immunol
. 1998 Apr;
160(7):3403-11.
PMID: 9531300
The mechanisms by which T cells from previously unexposed hosts respond in vitro to certain intracellular pathogens remain to be fully understood. We report and characterize the in vitro reactivity...
15.
Subauste C, de Waal Malefyt R, Fuh F
J Immunol
. 1998 Feb;
160(4):1831-40.
PMID: 9469444
The costimulatory ligands CD80 and CD86 play a crucial role in the initiation and maintenance of an immune response. We demonstrate that whereas infection of human monocytes with viable tachyzoites...
16.
Koppelman B, Neefjes J, De Vries J, de Waal Malefyt R
Immunity
. 1998 Jan;
7(6):861-71.
PMID: 9430231
Interleukin-10 (IL-10) inhibits antigen-specific T cell responses when human monocytes are used as antigen-presenting cells. This is correlated with a down-regulation of MHC class II molecules on the surface of...
17.
Schmidt S, Linington C, Zipp F, Sotgiu S, de Waal Malefyt R, Wekerle H, et al.
Brain
. 1997 Aug;
120 ( Pt 8):1437-45.
PMID: 9278633
The adoptive transfer of autoreactive S100 beta-specific T cells induces experimental autoimmune panencephalomyelitis and uveoretinitis in the Lewis rat, mimicking the distribution of lesions seen in a subset of patients...
18.
de Waal Malefyt R
Semin Oncol
. 1997 Jun;
24(3 Suppl 9):S9-94-S9-98.
PMID: 9208878
T-helper cells are compartmentalized according to the cytokines they are able to produce. T-helper 1 cells produce interleukin-2 (IL-2) and interferon-gamma (IFN-gamma), and develop following priming with IL-12. T-helper 2...
19.
Meinl E, Fickenscher H, Hoch R, Malefyt R, de Waal Malefyt R, t Hart B, et al.
Virology
. 1997 Mar;
229(1):175-82.
PMID: 9123859
This study aims in establishing the in vitro basis for a primate model to evaluate potential applications of H. saimiri-transformed T cells. T cell lines specific for myelin basic protein...
20.
Meinl E, Hoch R, Dornmair K, de Waal Malefyt R, Bontrop R, Jonker M, et al.
Am J Pathol
. 1997 Feb;
150(2):445-53.
PMID: 9033260
Myelin basic protein (MBP)-specific T cells are implicated in the pathogenesis of multiple sclerosis and are targets of selective immunotherapies. However, autoantigen-specific T cells can also be isolated from healthy...