R Datema
Overview
Explore the profile of R Datema including associated specialties, affiliations and a list of published articles.
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Articles
51
Citations
677
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Recent Articles
1.
Rabin L, Hincenbergs M, Moreno M, Warren S, Linquist V, Datema R, et al.
Antimicrob Agents Chemother
. 1996 Mar;
40(3):755-62.
PMID: 8851606
We have developed standardized procedures and practices for infection of SCID-hu Thy/Liv mice with human immunodeficiency virus type 1 for the prophylactic administration of antiviral compounds and for evaluation of...
2.
Datema R, Rabin L, Hincenbergs M, Moreno M, Warren S, Linquist V, et al.
Antimicrob Agents Chemother
. 1996 Mar;
40(3):750-4.
PMID: 8851605
SID 791, a bicyclam inhibiting human immunodeficiency virus (HIV) replication in vitro by blocking virus entry into cells, is an effective inhibitor of virus production and of depletion of human...
3.
De Vreese K, Leutgeb C, Weber V, Vermeire K, Schacht S, Anne J, et al.
J Virol
. 1996 Feb;
70(2):689-96.
PMID: 8551604
Bicyclams are a novel class of antiviral compounds which act as potent and selective inhibitors of the replication of human immunodeficiency virus type 1 (HIV-1) and HIV-2. They block an...
4.
Rosenwirth B, Billich A, Datema R, Donatsch P, Hammerschmid F, Harrison R, et al.
Antimicrob Agents Chemother
. 1994 Aug;
38(8):1763-72.
PMID: 7527198
(Me-Ile-4)cyclosporin (SDZ NIM 811) is a 4-substituted cyclosporin which is devoid of immunosuppressive activity but retains full capacity for binding to cyclophilin and exhibits potent anti-human immunodeficiency virus type 1...
5.
De Clercq E, Yamamoto N, Pauwels R, Balzarini J, Witvrouw M, De Vreese K, et al.
Antimicrob Agents Chemother
. 1994 Apr;
38(4):668-74.
PMID: 7913308
Bicyclams, in which the cyclam (1,4,8,11-tetraazacyclotetradecane) moieties are tethered via an aliphatic bridge (i.e., propylene, as in JM2763) are potent and selective inhibitors of human immunodeficiency virus type 1 (HIV-1)...
6.
Yu K, Bronson J, Yang H, Patick A, Alam M, Brankovan V, et al.
J Med Chem
. 1993 Sep;
36(19):2726-38.
PMID: 8410987
A series of 2'-substituted derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and evaluated in vitro for anti-human immunodeficiency virus (HIV) activity in the XTT assay and for anti-herpes activity...
7.
Yu K, Bronson J, Yang H, Patick A, Alam M, Brankovan V, et al.
J Med Chem
. 1992 Aug;
35(16):2958-69.
PMID: 1323678
A number of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG, 1) have been synthesized and tested in vitro for anti-herpes and anti-human immunodeficiency virus (HIV) activity. Among these analogues, (R)-2'-methyl-PMEG [(R)-3] and...
8.
Yang H, Datema R
Antimicrob Agents Chemother
. 1991 Aug;
35(8):1596-600.
PMID: 1929331
The acyclic nucleotide analog (S)-1-[(3-hydroxy-2-phosphonylmethoxy)propyl]cytosine (HPMPC) is a potent and selective inhibitor of herpesviruses. Cells preincubated with HPMPC are refractory to herpes simplex virus type 2 (HSV-2) infection for several...
9.
Olofsson S, Sjoblom I, Glorioso J, Jeansson S, Datema R
J Gen Virol
. 1991 Aug;
72 ( Pt 8):1959-65.
PMID: 1714943
We have described two types of oligosaccharide modification influencing the antigenicity of the herpes simplex virus type 1 (HSV-1)-specified glycoprotein C (gC-1). First, the expression of several epitopes belonging to...
10.