R D Gerard
Overview
Explore the profile of R D Gerard including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
2145
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Recent Articles
1.
Ballard E, Trinh V, Hogg R, Gerard R
Cancer Gene Ther
. 2012 May;
19(7):476-88.
PMID: 22595794
Adenovirus serotype 5 remains one of the most promising vectors for delivering genetic material to cancer cells for imaging or therapy, but optimization of these agents to selectively promote tumor...
2.
Card P, Hogg R, Gil del Alcazar C, Gerard R
Cancer Gene Ther
. 2012 May;
19(7):451-9.
PMID: 22555510
Adenoviral technology has been thoroughly evaluated for delivering genetic material to tumor tissue and the surrounding microenvironment. Almost any gene can be cloned into an adenovirus (Ad) vector, which when...
3.
Gerard R, Meidell R
Trends Cardiovasc Med
. 2011 Jan;
3(5):171-7.
PMID: 21244929
The introduction of foreign genetic material into somatic cells in intact organisms is an important investigational technique that holds considerable promise as a therapeutic tool. Although successful gene transfer has...
4.
Hogg R, Thorpe P, Gerard R
Cancer Gene Ther
. 2010 Dec;
18(4):275-87.
PMID: 21183946
Gene targeting to tumors using adenoviral (Ad) vectors holds great potential for cancer imaging and therapy, but the limited efficacy of current methods used to improve delivery to target tissues...
5.
Hogg R, Garcia J, Gerard R
Cancer Gene Ther
. 2010 Feb;
17(6):375-86.
PMID: 20139924
Using biochemical, imaging and histological methods, we employed transcriptional targeting to increase the specificity of tumor gene expression in vivo for intravenously administered recombinant adenovirus vectors. Surprisingly, the relative specificity...
6.
Zoppi S, Allman D, Gerard R, McPhaul M
J Mol Endocrinol
. 2001 Nov;
27(3):321-8.
PMID: 11719284
The androgen receptor (AR) and closely related members of the steroid receptor family have proven difficult to obtain in native form in large quantities. In the case of the human...
7.
Vanaken H, Gerard R, Verrijdt G, Haelens A, ROMBAUTS W, Claessens F
J Steroid Biochem Mol Biol
. 2001 Nov;
78(4):319-28.
PMID: 11717002
The lacrimal gland secretes most of the water and many proteins present in tear fluid. The composition of the tear fluid is affected dramatically by androgens, an observation which has...
8.
Israel B, Pickles R, Segal D, Gerard R, Kenney S
J Virol
. 2001 May;
75(11):5215-21.
PMID: 11333903
Although many recombinant adenovirus vectors (rAd) have been developed, especially by using group C adenoviruses, to transfer and express genes, such rAd do not readily infect B-cell lines due to...
9.
Bajou K, Masson V, Gerard R, Schmitt P, Albert V, Praus M, et al.
J Cell Biol
. 2001 Mar;
152(4):777-84.
PMID: 11266468
The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and tumor cell migration. Consequently, urokinase-type PA (uPA)/plasmin antagonists are currently...
10.
Varenne O, Sinnaeve P, Gillijns H, Iung B, Laurysens V, Meurrens K, et al.
Hum Gene Ther
. 2000 Jul;
11(9):1329-39.
PMID: 10890742
Local intracoronary delivery of recombinant adenoviruses expressing anti-migratory or anti-proliferative proteins including human constitutive endothelial nitric oxide synthase (NOS3), plasminogen activator inhibitor 1 (PAI-1), or herpesvirus thymidine kinase (TK) (combined...