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R Bland

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Articles 58
Citations 1166
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Recent Articles
11.
Cooper M, Bujalska I, Rabbitt E, Walker E, Bland R, Sheppard M, et al.
J Bone Miner Res . 2001 Jun; 16(6):1037-44. PMID: 11393780
Tissue damage by proinflammatory cytokines is attenuated at both systemic and cellular levels by counter anti-inflammatory factors such as corticosteroids. Target cell responses to corticosteroids are dependent on several factors...
12.
Eyre L, Rabbitt E, Bland R, Hughes S, Cooper M, Sheppard M, et al.
J Cell Biochem . 2001 Mar; 81(3):453-62. PMID: 11255228
11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) acts as a pre-receptor signaling mechanism for corticosteroids by regulating the access of active glucocorticoids to both glucocorticoid (GR) and mineralocorticoid receptors (MR). To examine...
13.
Zehnder D, Bland R, Williams M, McNinch R, Howie A, Stewart P, et al.
J Clin Endocrinol Metab . 2001 Feb; 86(2):888-94. PMID: 11158062
The mitochondrial enzyme 25-hydroxyvitamin D(3)-1 alpha-hydroxylase (1 alpha-hydroxylase) plays an important role in calcium homeostasis by catalyzing synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D(3), in the kidney....
14.
Hewison M, Zehnder D, Bland R, Stewart P
J Mol Endocrinol . 2000 Oct; 25(2):141-8. PMID: 11013342
The active form of vitamin D, 1,25-dihydroxvitamin D(3) (1, 25(OH)(2)D(3)), is a pleiotropic hormone whose actions include the regulation of calcium homeostasis, control of bone cell differentiation and modification of...
15.
Cooper M, Walker E, Bland R, Fraser W, Hewison M, Stewart P
Bone . 2000 Aug; 27(3):375-81. PMID: 10962348
Glucocorticoids have an essential role in skeletal development and function but are detrimental in excess. In several tissues, glucocorticoid action is dependent upon the expression of 11beta-hydroxysteroid dehydrogenase (11beta-HSD) isozymes,...
16.
Bland R
Clin Sci (Lond) . 2000 Feb; 98(2):217-40. PMID: 10657279
The skeleton is a complex tissue, and hormonal control of bone remodelling is elaborate. The important role that steroid hormones play in bone cell development and in the maintenance of...
17.
Bland R, Zehnder D, Hewison M
Curr Opin Nephrol Hypertens . 2000 Feb; 9(1):17-22. PMID: 10654820
Renal synthesis of the active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], is a pivotal step in calcium and phosphate homeostasis. Production of 1,25(OH)2D3 is catalyzed by the mitchondrial cytochrome...
18.
Billingham R, Bland R, Leary A
Psychol Rep . 1999 Dec; 85(2):574-8. PMID: 10611789
Data collected over the past 10 years were used to investigate whether there have been changes in the incidence of violence when dating reported at a large university. Responses to...
19.
Zehnder D, Bland R, Walker E, Bradwell A, Howie A, Hewison M, et al.
J Am Soc Nephrol . 1999 Dec; 10(12):2465-73. PMID: 10589683
The secosteroid hormone 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) plays a vital role in calcium metabolism, tissue differentiation, and normal bone growth. Biosynthesis of 1,25(OH)2D3 is catalyzed by the mitochondrial cytochrome P450 enzyme...
20.
Janssen J, Bland R, Hewison M, Coughtrie M, Sharp S, Arts J, et al.
J Cell Biochem . 1999 Oct; 75(3):528-37. PMID: 10536374
The importance of estrogens in bone metabolism is illustrated by the accelerated bone loss and increase in osteoporotic fractures associated with postmenopausal estrogen deficiency. In this study, the expression and...