S V Hughes
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Explore the profile of S V Hughes including associated specialties, affiliations and a list of published articles.
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12
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72
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Recent Articles
1.
Bland R, Zehnder D, Hughes S, Ronco P, Stewart P, Hewison M
Kidney Int
. 2001 Sep;
60(4):1277-86.
PMID: 11576342
Background: Recent studies have shown that renal expression of 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-OHase) is not restricted to proximal tubules. To investigate the significance of this expression, we characterized the regulation of...
2.
Eyre L, Rabbitt E, Bland R, Hughes S, Cooper M, Sheppard M, et al.
J Cell Biochem
. 2001 Mar;
81(3):453-62.
PMID: 11255228
11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) acts as a pre-receptor signaling mechanism for corticosteroids by regulating the access of active glucocorticoids to both glucocorticoid (GR) and mineralocorticoid receptors (MR). To examine...
3.
English M, Hughes S, Kane K, Langman M, Stewart P, Hewison M
Br J Cancer
. 2000 Aug;
83(4):550-8.
PMID: 10945506
Epidemiological data suggest that oestrogen contributes to the aetiology of colonic cancer. Furthermore, recent studies have suggested that local hormone metabolism may play a key role in determining colonic responsiveness...
4.
Bland R, Walker E, Hughes S, Stewart P, Hewison M
Endocrinology
. 1999 Apr;
140(5):2027-34.
PMID: 10218951
Circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) are dependent on activity of the renal mitochondrial cytochrome P450 enzyme, 25-hydroxyvitamin D3-1alpha-hydroxylase (1alpha-hydroxylase). Production of 1,25-(OH)2D3 occurs...
5.
Mountford J, Bunce C, Hughes S, Drayson M, Webb D, Brown G, et al.
Exp Hematol
. 1999 Mar;
27(3):451-60.
PMID: 10089907
Hormones such as 1 alpha, 25-dihydroxy vitamin D3 (D3), all-trans retinoic acid, and 9-cis retinoic acid stimulate differentiation of myeloid progenitor cells via their interaction with specific hormone receptors. However,...
6.
Dabrowski M, Robinson E, Hughes S, Bland R, Hewison M
Mol Cell Endocrinol
. 1998 Oct;
142(1-2):131-9.
PMID: 9783909
To characterize further the function of the intracellular vitamin D receptor (VDR), we have developed stable transfectant variants of a vitamin D-responsive cell line (U937) which express either decreased or...
7.
Hughes S, Robinson E, Bland R, Lewis H, Stewart P, Hewison M
Endocrinology
. 1997 Sep;
138(9):3711-8.
PMID: 9275056
Local estrogen metabolism may play an important role in modulating cell development in peripheral tissues such as breast, adipose, and bone. C19 androgens are converted to C18 estrogens by the...
8.
Bowden S, Emly J, Hughes S, Powell G, Ahmed A, Whittle M, et al.
J Endocrinol
. 1994 Aug;
142(2):217-24.
PMID: 7930994
Parathyroid hormone-related protein (PTHrP), the hypercalcaemia of malignancy factor, is expressed in the tissues of the human uteroplacental unit, including the placenta, amnion and chorion. We have used three region-specific...
9.
Hutchesson A, Hughes S, Bowden S, Ratcliffe W
Ann Clin Biochem
. 1994 Jan;
31 ( Pt 1):35-9.
PMID: 7512317
We describe a systematic comparison of the effects of anticoagulants, protease inhibitors and conditions of sample handling on the in vitro stability of endogenous parathyroid hormone-related protein (PTHrP) in blood...
10.
Bowden S, Hughes S, Ratcliffe W
Clin Endocrinol (Oxf)
. 1993 Mar;
38(3):287-94.
PMID: 8458100
Objective: We investigated the content and compared the molecular forms of parathyroid hormone-related protein in tumour tissue, plasma and pleural fluid. Design: Measurement of parathyroid hormone-related protein in tumour extracts...