R B Sartor
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Explore the profile of R B Sartor including associated specialties, affiliations and a list of published articles.
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109
Citations
4760
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Recent Articles
1.
Ulici V, Kelley K, Azcarate-Peril M, Cleveland R, Sartor R, Schwartz T, et al.
Osteoarthritis Cartilage
. 2018 Jun;
26(8):1098-1109.
PMID: 29857156
Objective: To determine the contribution of the gut microbiota to the development of injury-induced osteoarthritis (OA). Design: OA was induced using the destabilized medial meniscus (DMM) model in 20 germ-free...
2.
Ho G, Aird R, Liu B, Boyapati R, Kennedy N, Dorward D, et al.
Mucosal Immunol
. 2017 Apr;
11(1):120-130.
PMID: 28401939
The multidrug resistance-1 (MDR1) gene encodes an ATP-dependent efflux transporter that is highly expressed in the colon. In mice, loss of MDR1 function results in colitis with similarities to human...
3.
Kang D, Kakiyama G, Betrapally N, Herzog J, Nittono H, Hylemon P, et al.
Clin Transl Gastroenterol
. 2016 Aug;
7(8):e187.
PMID: 27560928
Objectives: Rifaximin has clinical benefits in minimal hepatic encephalopathy (MHE) but the mechanism of action is unclear. The antibiotic-dependent and -independent effects of rifaximin need to be elucidated in the...
4.
Sartor R
Aliment Pharmacol Ther
. 2015 Dec;
43 Suppl 1:27-36.
PMID: 26618923
Background: Gut microbiota dysbiosis contributes to the pathogenesis of inflammatory bowel diseases (IBD). Although the microbiota's role in IBD pathogenesis, specifically Crohn's disease (CD), provides a rationale for antibiotic treatment,...
5.
Waldschmitt N, Berger E, Rath E, Sartor R, Weigmann B, Heikenwalder M, et al.
Mucosal Immunol
. 2014 May;
7(6):1452-66.
PMID: 24850428
Loss of intestinal epithelial cell (IEC) homeostasis and apoptosis negatively affect intestinal barrier function. Uncontrolled activation of the unfolded protein response (UPR) in IEC contributes to an impaired barrier and...
6.
Sartor R
Mucosal Immunol
. 2011 Jan;
4(2):127-32.
PMID: 21248723
Co-evolution with an extremely complex commensal enteric microbiota has helped shape mammalian mucosal immune responses. A yet incompletely defined subset of intestinal bacteria is required to stimulate chronic, immune-mediated intestinal...
7.
Pawlowski S, Calabrese G, Kolling G, Platts-Mills J, Freire R, AlcantaraWarren C, et al.
J Infect Dis
. 2010 Oct;
202(11):1708-12.
PMID: 20977342
The increased incidence and severity of Clostridium difficile infection (CDI) in older adults (age, ≥65 years) corresponds with the emergence of the BI/NAP1 strain, making elucidation of the host immune...
8.
Kim J, An H, Rieter W, Esserman D, Taylor-Pashow K, Sartor R, et al.
Clin Exp Rheumatol
. 2009 Sep;
27(4):580-6.
PMID: 19772788
Objectives: This report documents a multimodal nanoparticle (MNP) contrast agent, containing embedded luminophores and surface-immobilized gadolinium chelates, as a contrast agent of inflamed synovium in a collagen induced arthritis (CIA)...
9.
Larmonier C, Uno J, Lee K, Karrasch T, Laubitz D, Thurston R, et al.
Am J Physiol Gastrointest Liver Physiol
. 2008 Sep;
295(5):G1079-91.
PMID: 18818316
Curcumin (diferulolylmethane) demonstrates profound anti-inflammatory effects in intestinal epithelial cells (IEC) and in immune cells in vitro and exhibits a protective role in rodent models of chemically induced colitis, with...
10.
Packey C, Sartor R
J Intern Med
. 2008 May;
263(6):597-606.
PMID: 18479259
Enteric microbiota can contribute to Crohn's disease and ulcerative colitis in several ways. Pathogenic or functionally altered commensal bacteria with increased mucosal adherence, invasion and intracellular persistence can activate pathogenic...