R B MERRIFIELD
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Explore the profile of R B MERRIFIELD including associated specialties, affiliations and a list of published articles.
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Articles
128
Citations
2249
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Recent Articles
1.
Barany M, Hammer R, MERRIFIELD R, Barany G
J Am Chem Soc
. 2005 Jan;
127(2):508-9.
PMID: 15643859
The 1,2,4-dithiazolidine-3,5-dione heterocycle, also referred to as a dithiasuccinoyl (Dts)-amine, serves as a readily removable amino protecting group for building blocks used in syntheses of peptides, glycopeptides, and PNA; it...
2.
Arrow K, Axelrod J, Benacerraf B, Berg P, Bishop J, BLOEMBERGEN N, et al.
Washington Post
. 2002 Dec;
:A02.
PMID: 12462241
No abstract available.
3.
Unson C, Jiang Y, Yoo B, Cheung C, Sakmar T, MERRIFIELD R
Biochemistry
. 2002 Sep;
41(39):11795-803.
PMID: 12269822
To identify structural determinants of ligand binding in the glucagon receptor, eight receptor chimeras and additional receptor point mutants were prepared and studied. Amino acid residues 103-117 and 126-137 in...
4.
Jiang Y, Cypess A, Muse E, Wu C, Unson C, MERRIFIELD R, et al.
Proc Natl Acad Sci U S A
. 2001 Aug;
98(18):10102-7.
PMID: 11517300
We prepared a stable cell line expressing the glucagon receptor to characterize the effect of G(s)-coupled receptor stimulation on extracellular signal-regulated protein kinase 1/2 (ERK1/2) activity. Glucagon treatment of the...
5.
Robinson N, Robinson A, MERRIFIELD R
J Pept Res
. 2001 Jul;
57(6):483-93.
PMID: 11437952
Solid-phase peptide synthesis and deamidation measurements using a novel mass spectrometric technique were carried out for 94 model asparaginyl peptides from 3 to 13 residues in length. Deamidation rates of...
6.
Unson C, Wu C, Sakmar T, MERRIFIELD R
J Biol Chem
. 2000 May;
275(28):21631-8.
PMID: 10791965
To analyze functional differences in the interactions of the glucagon receptor (GR) with the two predominant splice variants of Galpha(s), GR was covalently linked to the short and the long...
7.
Marassi F, Opella S, Juvvadi P, MERRIFIELD R
Biophys J
. 1999 Dec;
77(6):3152-5.
PMID: 10585936
The orientation of the insect antibiotic peptide cecropin A (CecA) in the phospholipid bilayer membrane was determined using (15)N solid-state NMR spectroscopy. Two peptide samples, each specifically labeled with (15)N...
8.
Juvvadi P, Vunnam S, Yoo B, MERRIFIELD R
J Pept Res
. 1999 May;
53(3):244-51.
PMID: 10231712
Chimeric analogs of cecropin P1 and melittin with normal and retro sequences were synthesized to explore the effect of sequence, amide bond direction (helical dipole), charge, amphipathicity and hydrophobicity on...
9.
Unson C, Wu C, Cheung C, MERRIFIELD R
J Biol Chem
. 1998 May;
273(17):10308-12.
PMID: 9553084
Glucagon is a peptide hormone that plays a central role in the maintenance of normal circulating glucose levels. Structure-activity studies have previously demonstrated the importance of histidine at position 1...
10.
Vunnam S, Juvvadi P, Rotondi K, MERRIFIELD R
J Pept Res
. 1998 Mar;
51(1):38-44.
PMID: 9495589
In our effort to understand the structural requirements for the antimicrobial activity of cecropin A (CA) and melittin (M), we synthesized the normal, enantio, retro and retroenantio hybrid analogs; we...