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R B Innis

Explore the profile of R B Innis including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 133
Citations 4190
Followers 0
Related Specialties
Psychiatry
Nuclear Medicine
Neurology
Top 10 Co-Authors
R M Baldwin
D S Charney
J P Seibyl
S S Zoghbi
M Laruelle
Y Zea-Ponce
M Fujita
C H van Dyck
A Abi-Dargham
S H Snyder
Published In
J Nucl Med
Am J Psychiatry
Eur J Pharmacol
Nucl Med Biol
Biol Psychiatry
Affiliations
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Recent Articles
1.
cAMP signaling in brain is decreased in unmedicated depressed patients and increased by treatment with a selective serotonin reuptake inhibitor
Fujita M, Richards E, Niciu M, Ionescu D, Zoghbi S, Hong J, et al.
Mol Psychiatry . 2016 Oct; 22(5):754-759. PMID: 27725657
Basic studies exploring the importance of the cyclic adenosine monophosphate (cAMP) cascade in major depressive disorder (MDD) have noted that the cAMP cascade is downregulated in MDD and upregulated by...
2.
Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography
Hirvonen J, Zanotti-Fregonara P, Umhau J, George D, Rallis-Frutos D, Lyoo C, et al.
Mol Psychiatry . 2012 Jul; 18(8):916-21. PMID: 22776901
Brain cannabinoid CB1 receptors contribute to alcohol-related behaviors in experimental animals, but their potential role in humans with alcohol dependence is poorly understood. We measured CB1 receptors in alcohol dependent...
3.
Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
Hirvonen J, Goodwin R, Li C, Terry G, Zoghbi S, Morse C, et al.
Mol Psychiatry . 2011 Jul; 17(6):642-9. PMID: 21747398
Chronic cannabis (marijuana, hashish) smoking can result in dependence. Rodent studies show reversible downregulation of brain cannabinoid CB(1) (cannabinoid receptor type 1) receptors after chronic exposure to cannabis. However, whether...
4.
Imaging the function of P-glycoprotein with radiotracers: pharmacokinetics and in vivo applications
Kannan P, John C, Zoghbi S, Halldin C, Gottesman M, Innis R, et al.
Clin Pharmacol Ther . 2009 Jul; 86(4):368-77. PMID: 19625998
P-glycoprotein (P-gp), an efflux transporter, controls the pharmacokinetics of various compounds under physiological conditions. P-gp-mediated drug efflux has been suggested as playing a role in various disorders, including multidrug-resistant cancer...
5.
Radiation dosimetry estimates for the PET serotonin transporter probe 11C-DASB determined from whole-body imaging in non-human primates
Tipre D, Lu J, Fujita M, Ichise M, Vines D, Innis R
Nucl Med Commun . 2004 Apr; 25(1):81-6. PMID: 15061269
The radiotracer 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile labelled in the N-methyl position (11C-DASB) is a selective radioligand for the in vivo quantification of serotonin transporters (SERTs) using positron emission tomography (PET). The current study...
6.
[(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson's disease and multiple system atrophy
Varrone A, Marek K, Jennings D, Innis R, Seibyl J
Mov Disord . 2001 Dec; 16(6):1023-32. PMID: 11748733
In vivo imaging of the dopamine transporter (DAT) with single photon emission computed tomography (SPECT) is a quantitative biomarker for Parkinson's disease (PD) onset and severity. This study has examined...
7.
Sex differences in [123I]beta-CIT SPECT measures of dopamine and serotonin transporter availability in healthy smokers and nonsmokers
Staley J, Krishnan-Sarin S, Zoghbi S, Tamagnan G, Fujita M, Seibyl J, et al.
Synapse . 2001 Aug; 41(4):275-84. PMID: 11494398
Nicotine and other constituents of tobacco smoke elevate dopamine (DA) and serotonin (5-HT) levels in brain and may cause homeostatic adaptations in DA and 5-HT transporters. Since sex steroids alter...
8.
Comparison of [(18)F]altanserin and [(18)F]deuteroaltanserin for PET imaging of serotonin(2A) receptors in baboon brain: pharmacological studies
Staley J, van Dyck C, Tan P, Al Tikriti M, Ramsby Q, Klump H, et al.
Nucl Med Biol . 2001 Apr; 28(3):271-9. PMID: 11323237
The regional distribution in brain, distribution volumes, and pharmacological specificity of the PET 5-HT(2A) receptor radiotracer [(18)F]deuteroaltanserin were evaluated and compared to those of its non-deuterated derivative [(18)F]altanserin. Both radiotracers...
9.
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, et al.
Psychiatry Res . 2001 Apr; 106(2):81-93. PMID: 11306248
The test/retest reproducibility of brain measures of 5-HT2A receptors with positron emission tomography (PET) and [18F]deuteroaltanserin was examined in a group of eight healthy human subjects. PET measures of 5-HT2A...
10.
The variable number of tandem repeats polymorphism of the dopamine transporter gene is not associated with significant change in dopamine transporter phenotype in humans
Martinez D, Gelernter J, Abi-Dargham A, van Dyck C, Kegeles L, Innis R, et al.
Neuropsychopharmacology . 2001 Apr; 24(5):553-60. PMID: 11282255
A 40 base polymorphism of a variable number of tandem repeats (VNTR) has been described in the 3' untranslated region of the gene (SLC6A3) coding for the dopamine transporter (DAT)....