R B Hochberg
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Explore the profile of R B Hochberg including associated specialties, affiliations and a list of published articles.
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85
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Recent Articles
1.
Labaree D, Reynolds T, Hochberg R
J Med Chem
. 2001 May;
44(11):1802-14.
PMID: 11356114
We attempted to design analogues of estradiol to act as locally active estrogens without significant systemic action. We synthesized a series of 16alpha-carboxylic acid substituted steroids and their esters and...
2.
Garg P, Labaree D, Hoyte R, Hochberg R
Nucl Med Biol
. 2001 Feb;
28(1):85-90.
PMID: 11182568
We have synthesized a 18F-labeled androgen, [7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone, in a no-carrier-added radiosynthesis by exchange of 18F- (tetrabutylammonium fluoride) with the 7beta-tosyloxy of 17alpha-methyl-5alpha-dihydrotestosterone. The nonradioactive steroid binds with high affinity and...
3.
Kanji S, Kuohung W, Labaree D, Hochberg R
J Clin Endocrinol Metab
. 1999 Jul;
84(7):2481-8.
PMID: 10404824
Lecithin:cholesterol acyltransferase (LCAT), the enzyme that esterifies cholesterol in blood, also esterifies other steroids at the 3beta-hydroxyl. These steroids, like cholesterol, are delta5-3beta-hydroxysteroids, such as pregnenolone and dehydroepiandrosterone. One unusual...
4.
Labaree D, Hoyte R, Nazareth L, Weigel N, Hochberg R
J Med Chem
. 1999 Jun;
42(11):2021-34.
PMID: 10354410
We have synthesized several 7alpha-fluoro (F) and 7alpha-iodo (I) analogues of 5alpha-dihydrotestosterone (5alpha-DHT) and 19-nor-5alpha-dihydrotestosterone (5alpha-NDHT) and tested them for binding to the androgen receptor and for their biological activity...
5.
Hoyte R, Labaree D, Fede J, Harris C, Hochberg R
Steroids
. 1998 Nov;
63(11):595-602.
PMID: 9830686
We have synthesized several halogenated steroids as potential glucocorticoid receptor mediated imaging agents. These compounds are analogs of aryl-pyrazolo steroids, similar to the potent glucocorticoid, cortivazol. Compounds containing the halogens,...
6.
7.
Maclusky N, Bowlby D, Brown T, Peterson R, Hochberg R
Neurochem Res
. 1997 Nov;
22(11):1395-414.
PMID: 9355112
The developmental effects of androgen play a central role in sexual differentiation of the mammalian central nervous system. The cellular mechanisms responsible for mediating these effects remain incompletely understood. A...
8.
Labaree D, Hoyte R, Hochberg R
Steroids
. 1997 Jun;
62(6):482-6.
PMID: 9185296
Although 7 beta-hydroxytestosterone is a known product of hepatic androgen metabolism, there are no published methods for its chemical synthesis except from the equally difficult to obtain 7 beta-hydroxy-4-androstene-3,17-dione. We...
9.
7 alpha-iodine-125-iodo-5 alpha-dihydrotestosterone: a radiolabeled ligand for the androgen receptor
Labaree D, Brown T, Hoyte R, Hochberg R
J Nucl Med
. 1997 Mar;
38(3):402-9.
PMID: 9074528
Unlabelled: We describe the preparation of 7 alpha-[125I]iodo-5 alpha-dihydrotestosterone (7 alpha-[125I]IDHT) and its characterization as a ligand for the androgen receptor. Methods: We designed a route to prepare the radioiodine-labeled...
10.
Brown T, Scherz B, Hochberg R, Maclusky N
Neuroendocrinology
. 1996 Jan;
63(1):53-60.
PMID: 8839355
To determine whether estrogen and androgens either alone or in combination downregulate estrogen receptors in the brain, ovariectomized/adrenalectomized female rats received one of the following four treatments: (1) one subcutaneously...