R Alex Wu
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Explore the profile of R Alex Wu including associated specialties, affiliations and a list of published articles.
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10
Citations
546
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Recent Articles
1.
Can G, Shyian M, Krishnamoorthy A, Lim Y, Wu R, Zaher M, et al.
bioRxiv
. 2024 Dec;
PMID: 39651145
When cells enter mitosis with under-replicated DNA, sister chromosome segregation is compromised, which can lead to massive genome instability. The replisome-associated E3 ubiquitin ligase TRAIP mitigates this threat by ubiquitylating...
2.
Kochenova O, DAlessandro G, Pilger D, Schmid E, Richards S, Garcia M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282314
The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of...
3.
Vrtis K, Dewar J, Chistol G, Wu R, Graham T, Walter J
Mol Cell
. 2021 Jan;
81(6):1309-1318.e6.
PMID: 33484638
DNA damage impedes replication fork progression and threatens genome stability. Upon encounter with most DNA adducts, the replicative CMG helicase (CDC45-MCM2-7-GINS) stalls or uncouples from the point of synthesis, yet...
4.
Wu R, Pellman D, Walter J
Trends Cell Biol
. 2020 Dec;
31(2):75-85.
PMID: 33317933
In preparation for cell division, the genome must be copied with high fidelity. However, replisomes often encounter obstacles, including bulky DNA lesions caused by reactive metabolites and chemotherapeutics, as well...
5.
Wang A, Chen L, Wu R, Hao Y, McSwiggen D, Heckert A, et al.
Mol Cell
. 2020 Jul;
79(2):221-233.e5.
PMID: 32603710
Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro but turns over rapidly when used to manipulate genomes in eukaryotic cells. Little is known about the...
6.
Deng L, Wu R, Sonneville R, Kochenova O, Labib K, Pellman D, et al.
Mol Cell
. 2019 Mar;
73(5):915-929.e6.
PMID: 30849395
DNA replication errors generate complex chromosomal rearrangements and thereby contribute to tumorigenesis and other human diseases. One mechanism that triggers these errors is mitotic entry before the completion of DNA...
7.
Wu R, Semlow D, Kamimae-Lanning A, Kochenova O, Chistol G, Hodskinson M, et al.
Nature
. 2019 Mar;
567(7747):267-272.
PMID: 30842657
Cells often use multiple pathways to repair the same DNA lesion, and the choice of pathway has substantial implications for the fidelity of genome maintenance. DNA interstrand crosslinks covalently link...
8.
Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Larsen N, Gao A, Sparks J, Gallina I, Wu R, Mann M, et al.
Mol Cell
. 2019 Jan;
73(3):574-588.e7.
PMID: 30595436
DNA-protein crosslinks (DPCs) are bulky lesions that interfere with DNA metabolism and therefore threaten genomic integrity. Recent studies implicate the metalloprotease SPRTN in S phase removal of DPCs, but how...
9.
Amunugama R, Willcox S, Wu R, Abdullah U, El-Sagheer A, Brown T, et al.
Cell Rep
. 2018 Jun;
23(12):3419-3428.
PMID: 29924986
DNA interstrand crosslinks (ICLs) are extremely cytotoxic, but the mechanism of their repair remains incompletely understood. Using Xenopus egg extracts, we previously showed that repair of a cisplatin ICL is...
10.
Wu R, Upton H, Vogan J, Collins K
Annu Rev Biochem
. 2017 Feb;
86:439-460.
PMID: 28141967
Telomerase is the essential reverse transcriptase required for linear chromosome maintenance in most eukaryotes. Telomerase supplements the tandem array of simple-sequence repeats at chromosome ends to compensate for the DNA...