R A Van Etten
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Explore the profile of R A Van Etten including associated specialties, affiliations and a list of published articles.
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50
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3048
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Recent Articles
1.
Gu S, Sayad A, Chan G, Yang W, Lu Z, Virtanen C, et al.
Leukemia
. 2017 Aug;
32(1):203-213.
PMID: 28804122
BCR-ABL1-targeting tyrosine kinase inhibitors (TKIs) have revolutionized treatment of Philadelphia chromosome-positive (Ph) hematologic neoplasms. Nevertheless, acquired TKI resistance remains a major problem in chronic myeloid leukemia (CML), and TKIs are...
2.
3.
Jena N, Sheng J, Hu J, Li W, Zhou W, Lee G, et al.
Leukemia
. 2015 Dec;
30(5):1033-43.
PMID: 26707936
T-cell acute lymphoblastic leukemia (T-ALL) is a high-risk subset of acute leukemia, characterized by frequent activation of Notch1 or AKT signaling, where new therapeutic approaches are needed. We showed previously...
4.
Walz C, Cross N, Van Etten R, Reiter A
Leukemia
. 2008 Jun;
22(7):1320-34.
PMID: 18528425
Constitutively activated mutants of the non-receptor tyrosine kinases (TK) ABL1 (Abelson murine leukemia viral (v-abl) homolog (1) protein) and JAK2 (JAnus Kinase 2 or Just Another Kinase 2) play a...
5.
Van Etten R
Oncogene
. 2007 Oct;
26(47):6738-49.
PMID: 17934482
Abnormalities of cytokine and growth factor signaling pathways are characteristic of all forms of leukemia: lymphoid and myeloid, acute and chronic. In normal hematopoietic cells, cytokines provide the stimulus for...
6.
Brain J, Kavet R, McCormick D, Poole C, Silverman L, Smith T, et al.
Environ Health Perspect
. 2003 Jun;
111(7):962-70.
PMID: 12782499
Numerous epidemiologic studies have reported associations between measures of power-line electric or magnetic fields (EMFs) and childhood leukemia. The basis for such associations remains unexplained. In children, acute lymphoblastic leukemia...
7.
Brasher B, Roumiantsev S, Van Etten R
Oncogene
. 2001 Dec;
20(53):7744-52.
PMID: 11753652
The catalytic activity of the c-Abl tyrosine kinase is tightly regulated by its Src homology 3 (SH3) domain through a complex mechanism that may involve intramolecular binding to Pro242 in...
8.
Li S, Couvillon A, Brasher B, Van Etten R
EMBO J
. 2001 Dec;
20(23):6793-804.
PMID: 11726515
Growth factor receptor-binding protein-2 (Grb2) plays a key role in signal transduction initiated by Bcr/Abl oncoproteins and growth factors, functioning as an adaptor protein through its Src homology 2 and...
9.
Van Etten R
Curr Opin Hematol
. 2001 Sep;
8(4):224-30.
PMID: 11561160
Several methods to model human Ph+ leukemia in laboratory mice are available, including propagation of BCR/ABL-expressing cells in mice, xenotransplantation of primary Ph+ leukemia cells into immunodeficient mice, BCR/ABL transgenic...
10.
Van Etten R
Blood Cells Mol Dis
. 2001 May;
27(1):201-5.
PMID: 11358380
There are two commonly used approaches to modeling human leukemia in mice: generation of mutant mice by traditional transgenic or knock-out/knock-in methods and retroviral bone marrow transduction and transplantation. For...