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R A Majack

Explore the profile of R A Majack including associated specialties, affiliations and a list of published articles. Areas
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Articles 31
Citations 733
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Recent Articles
1.
Schwartz P, Grieshaber N, Quinn B, Grieshaber S, Belknap J, Mourani P, et al.
Circ Res . 2000 Sep; 87(7):608-15. PMID: 11009567
We sought to identify and characterize the expression pattern of genes expressed by smooth muscle cells (SMCs) during periods of self-driven replication during vascular development and after vascular injury. Primary...
2.
Belknap J, Grieshaber S, Majack R, Stenmark K
Am J Respir Cell Mol Biol . 1998 Dec; 20(1):24-34. PMID: 9870914
Smooth-muscle-cell (SMC) replication and extracellular matrix protein expression are two vital and interrelated processes necessary for normal development of the vasculature. To understand better the nature of this relationship in...
3.
Weiser M, Grieshaber N, Schwartz P, Majack R
Mol Biol Cell . 1997 Jun; 8(6):999-1011. PMID: 9201711
Vascular smooth muscle cells (SMCs) are very quiescent in the mature vessel and exhibit a remarkable phenotype-dependent diversity in gene expression that may reflect the growth responsiveness of these cells...
4.
Weiser M, Belknap J, Grieshaber S, Kinsella M, Majack R
Matrix Biol . 1996 Nov; 15(5):331-40. PMID: 8981329
Heparan sulfate proteoglycans (HSPGs) are believed to act as potent endogenous regulators of vascular smooth muscle cell (SMC) replication, migration, gene expression and differentiation. Here we describe the pattern of...
5.
Morrell N, Grieshaber S, Danilov S, Majack R, Stenmark K
Am J Respir Cell Mol Biol . 1996 Jun; 14(6):526-37. PMID: 8652181
Factors that influence the development of the normal pulmonary vasculature are poorly understood. Since increased local production of angiotensin II (AII) by angiotensin converting enzyme (ACE) has been implicated in...
6.
Majack R, Grieshaber N, Cook C, Weiser M, McFall R, Grieshaber S, et al.
J Cell Physiol . 1996 Apr; 167(1):106-12. PMID: 8698827
A variety of evidence suggests that vascular smooth muscle cells (SMC) exhibit a more immature phenotype when stimulated by injury to replicate in the adult. One growth characteristic common to...
7.
Belknap J, Grieshaber N, Schwartz P, Orton E, Reidy M, Majack R
Circ Res . 1996 Mar; 78(3):388-94. PMID: 8593697
After vascular injury, quiescent adult smooth muscle cells (SMCs) revert to a more immature synthetic-state phenotype concomitant with the onset of cell replication. The relationship between SMC proliferation and the...
8.
Crowley S, RAY C, Nawaz D, Majack R, Horwitz L
Am J Physiol . 1995 Nov; 269(5 Pt 2):H1641-7. PMID: 7503260
Local release of mitogenic and chemotactic signals during angioplasty-induced vascular injury may initiate restenosis. We investigated whether mechanical injury to vascular smooth muscle cells (VSMC) results in the release of...
9.
Weiser M, Majack R, Tucker A, Orton E
Am J Physiol . 1995 Mar; 268(3 Pt 2):H1133-8. PMID: 7900867
During the development of pulmonary hypertension, vascular cell proliferation closely parallels the rise in pulmonary intravascular pressure. The possible direct physical effect that elevated pressures may have on inducing vascular...
10.
Florkiewicz R, Majack R, Buechler R, Florkiewicz E
J Cell Physiol . 1995 Mar; 162(3):388-99. PMID: 7860646
Although basic fibroblast growth factor (bFGF/FGF-2) is found outside cells, it lacks a conventional signal peptide sequence; the mechanism underlying its export from cells is therefore unknown. Using a transient...