R A Hegele
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Explore the profile of R A Hegele including associated specialties, affiliations and a list of published articles.
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231
Citations
2898
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Recent Articles
11.
12.
Ley S, Harris S, Connelly P, Mamakeesick M, Gittelsohn J, Wolever T, et al.
Diabetes Obes Metab
. 2012 Apr;
14(9):821-5.
PMID: 22510237
Aims: Traditional lipid indices have been associated with type 2 diabetes, but limited data are available regarding non-high-density lipoprotein (non-HDL) cholesterol. In view of recent guidelines for the clinical management...
13.
Surendran R, Visser M, Heemelaar S, Wang J, Peter J, Defesche J, et al.
J Intern Med
. 2012 Jan;
272(2):185-96.
PMID: 22239554
Objectives: The severe forms of hypertriglyceridaemia (HTG) are caused by mutations in genes that lead to the loss of function of lipoprotein lipase (LPL). In most patients with severe HTG...
14.
Lanktree M, Hegele R
Cytogenet Genome Res
. 2009 Mar;
123(1-4):169-75.
PMID: 19287152
Despite successes in identifying genetic contributors to common metabolic phenotypes, only part of the heritable component of these traits has thus far been explained. Copy number variation (CNV) is likely...
15.
Joy T, Hegele R
Br J Pharmacol
. 2008 Jun;
154(7):1379-81.
PMID: 18536741
The failure of the cholesterol ester transfer protein (CETP) inhibitor, torcetrapib, has led to questions regarding whether the molecule itself or the mechanism of CETP inhibition was responsible for the...
16.
Awan Z, Alrasadi K, Francis G, Hegele R, McPherson R, Frohlich J, et al.
Arterioscler Thromb Vasc Biol
. 2008 Feb;
28(4):777-85.
PMID: 18239150
Background: Patients with homozygous familial hypercholesterolemia (hmzFH) attributable to LDL receptor gene mutations have shown a remarkable increase in survival over the last 20 years. Early onset coronary heart disease...
17.
Lanktree M, Cao H, Rabkin S, Hanna A, Hegele R
Clin Genet
. 2007 Jan;
71(2):183-6.
PMID: 17250669
No abstract available.
18.
Hegele R, Ur E, Ransom T, Cao H
Clin Genet
. 2006 Sep;
70(4):360-2.
PMID: 16965332
No abstract available.
19.
Bhattacharya M, Wang J, Ribeiro F, Dixon S, Feldman R, Hegele R, et al.
Pharmacogenomics J
. 2006 Sep;
7(3):190-9.
PMID: 16953235
Formyl-Met-Leu-Phe (fMLP) is a potent chemoattractant molecule released from both bacteria and damaged mitochondria that activates fMLP receptors (FPR) leading to neutrophil chemotaxis, degranulation and superoxide production. A common missense...
20.
Pandey S, Pungavkar S, Vaidya R, Patkar D, Hegele R, Sheth F, et al.
J Assoc Physicians India
. 2006 Feb;
53:897-900.
PMID: 16459536
Familial Partial Lipodystrophy, Dunnigan type (FPLD), is characterised by loss of subcutaneous fat from the limbs and an excessive accumulation of fat on the neck, shoulder girdle and face. Affected...