R A Halpin
Overview
Explore the profile of R A Halpin including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
180
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Stucker K, Schobel S, Olsen R, Hodges H, Lin X, Halpin R, et al.
Euro Surveill
. 2015 May;
20(18).
PMID: 25990233
While the early start and higher intensity of the 2012/13 influenza A virus (IAV) epidemic was not unprecedented, it was the first IAV epidemic season since the 2009 H1N1 influenza...
2.
SantAnna F, Borges L, Fallavena P, Gregianini T, Matias F, Halpin R, et al.
Arch Virol
. 2013 Oct;
159(4):621-30.
PMID: 24114147
During the 2009 influenza A pH1N1 pandemics in Brazil, the state that was most affected was Rio Grande do Sul (RS), with over 3,000 confirmed cases, including 298 deaths. While...
3.
Baillie T, Halpin R, Matuszewski B, Geer L, Chavez-Eng C, Dean D, et al.
Drug Metab Dispos
. 2001 Nov;
29(12):1614-28.
PMID: 11717181
Rofecoxib is a potent and highly selective cyclooxygenase-2 inhibitor used for the treatment of osteoarthritis and pain. Following administration of [4-(14)C]rofecoxib to intact rats, the plasma C(max) (at approximately 1...
4.
Kassahun K, McIntosh I, Shou M, Walsh D, Rodeheffer C, Slaughter D, et al.
Drug Metab Dispos
. 2001 May;
29(6):813-20.
PMID: 11353749
Etoricoxib, a potent and selective cyclooxygenase-2 inhibitor, was shown to be metabolized via 6'-methylhydroxylation (M2 formation) when incubated with NADPH-fortified human liver microsomes. In agreement with in vivo data, 1'-N'-oxidation...
5.
Halpin R, Geer L, Zhang K, MARKS T, Dean D, Jones A, et al.
Drug Metab Dispos
. 2000 Sep;
28(10):1244-54.
PMID: 10997947
Absorption, distribution, metabolism, and excretion studies were conducted in rats and dogs with rofecoxib (VIOXX, MK-0966), a potent and highly selective inhibitor of cyclooxygenase-2 (COX-2). In rats, the nonexponential decay...
6.
Vyas K, Halpin R, Geer L, Ellis J, Liu L, Cheng H, et al.
Drug Metab Dispos
. 1999 Dec;
28(1):89-95.
PMID: 10611145
The absorption and disposition of rizatriptan (MK-0462, Maxalt(TM)), a selective 5-HT(1B/1D) receptor agonist used in the treatment of migraine headaches, was investigated in humans. In a two-period, single i.v. (3...
7.
Bell I, Erb J, Freidinger R, Gallicchio S, Guare J, Guidotti M, et al.
J Med Chem
. 1998 Jun;
41(12):2146-63.
PMID: 9622556
The previously reported oxytocin antagonist L-371,257 (2) has been modified at its acetylpiperidine terminus to incorporate various pyridine N-oxide groups. This modification has led to the identification of compounds with...
8.
McLoughlin D, Olah T, Ellis J, Gilbert J, Halpin R
J Chromatogr A
. 1996 Mar;
726(1-2):115-24.
PMID: 8900521
The 5HT1D agonist sumatriptan is efficacious in the treatment of migraines. MK-462 is a drug of the same class which is under development in our laboratories. Bioanalytical methods of high...
9.
Halpin R, Ulm E, Till A, Kari P, Vyas K, Hunninghake D, et al.
Drug Metab Dispos
. 1993 Nov;
21(6):1003-11.
PMID: 7905377
Lovastatin is a prodrug lactone whose open-chain 3,5-dihydroxy acid is a potent, competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, the rate-limiting enzyme in cholesterol biosynthesis. The compound undergoes extensive and complex...
10.
Vyas K, Kari P, Pitzenberger S, Halpin R, Ramjit H, Arison B, et al.
Drug Metab Dispos
. 1990 Mar;
18(2):203-11.
PMID: 1971574
Structures of in vitro microsomal and in vivo metabolites of lovastatin, a new cholesterol-lowering drug, were elucidated with the combined application of HPLC, UV, fast atom bombardment-MS, and NMR spectroscopy....