R A Giacobbe
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Explore the profile of R A Giacobbe including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
179
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Recent Articles
1.
Cabello M, Platas G, Collado J, Diez M, Martin I, Vicente F, et al.
Int Microbiol
. 2002 Jan;
4(2):93-102.
PMID: 11770831
Echinocandins, the lipopeptide class of glucan synthase inhibitors, are an alternative to ergosterol-synthesis inhibitors to treat candidiasis and aspergillosis. Their oral absorption, however, is low and they can only be...
2.
Vicente M, Cabello A, Platas G, Basilio A, Diez M, Dreikorn S, et al.
J Appl Microbiol
. 2001 Nov;
91(5):806-13.
PMID: 11722657
Aims: Natural fungal products were screened for antifungal compounds. The mode of action of one of the hits found and the taxonomy of the producing organism were analysed. Methods And...
3.
Pelaez F, Cabello A, Platas G, Diez M, Gonzalez del Val A, Basilio A, et al.
Syst Appl Microbiol
. 2000 Dec;
23(3):333-43.
PMID: 11108011
In a screening of natural products with antifungal activity derived from endophytic fungi, we detected a potent activity in a culture belonging to the form-genus Hormonema, isolated from leaves of...
4.
Ondeyka J, Giacobbe R, Bills G, Cuadrillero C, Schmatz D, Goetz M, et al.
Bioorg Med Chem Lett
. 1999 Feb;
8(24):3439-42.
PMID: 9934448
Coprophilin, a decalin pentanedienoic acid methyl ester, was isolated from an unidentified fungus by bioassay guided separation. It inhibited (MIC = 1.5 microM) the growth of Eimeria tenella in an...
5.
Goetz M, Bills G, Giacobbe R, Tkacz J, Chang R, Mojena M, et al.
J Antibiot (Tokyo)
. 1996 Feb;
49(2):119-23.
PMID: 8621349
Cytosporin A, B and C, three antagonists of [125I]-angiotensin II binding to rat adrenal glands were discovered in fermentations of an endophytic Cytospora sp. during routine screening using semi-automated procedures....
6.
Lee S, Hensens O, Helms G, Liesch J, ZINK D, Giacobbe R, et al.
J Nat Prod
. 1995 Dec;
58(12):1822-8.
PMID: 8691204
A novel oleic acid ester of the carotane sesquiterpene 14-hydroxy CAF-603 was isolated from Trichoderma virens grown in a solid brown rice-based medium, a solid millet-based medium, or a mannitol-based...
7.
Mandala S, Thornton R, Frommer B, Curotto J, Rozdilsky W, KURTZ M, et al.
J Antibiot (Tokyo)
. 1995 May;
48(5):349-56.
PMID: 7797434
Potent antifungal activity was detected in fermentation extracts of Sporormiella australis and two related components were isolated from solid fermentations using silica gel and high speed countercurrent chromatography. The most...
8.
Tkacz J, Giacobbe R, Monaghan R
J Ind Microbiol
. 1993 Feb;
11(2):95-103.
PMID: 7763443
We have developed a liquid fermentation medium for the submerged culture of the fungus, Zalerion arboricola, which supports the rapid production of an echinocandin-type antibiotic, pneumocandin A0 (formerly L-671,329), in...
9.
Lam Y, Wichmann C, Meinz M, Guariglia L, Giacobbe R, Mochales S, et al.
J Antibiot (Tokyo)
. 1992 Sep;
45(9):1397-403.
PMID: 1331013
A novel inositol mono-phosphatase inhibitor, L-671,776 (1), was discovered from a culture of the hyphomycete, Memnoniella echinata (ATCC 20928). 1 has a molecular weight of 388 and a molecular formula...
10.
Vanmiddlesworth F, Giacobbe R, Lopez M, Garrity G, Bland J, Bartizal K, et al.
J Antibiot (Tokyo)
. 1992 Jun;
45(6):861-7.
PMID: 1500351
In screening for antifungal inhibitors from fungi, four related antifungal agents have been isolated from the cultivation of Aspergillus fumigatus ATCC 20857. These agents were initially produced by the microorganism...