Qutuba G Karwi
Overview
Explore the profile of Qutuba G Karwi including associated specialties, affiliations and a list of published articles.
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Articles
36
Citations
1177
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Recent Articles
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2.
Sun Q, Karwi Q, Wong N, Lopaschuk G
Cardiovasc Res
. 2024 Oct;
120(16):1996-2016.
PMID: 39453987
The very high energy demand of the heart is primarily met by adenosine triphosphate (ATP) production from mitochondrial oxidative phosphorylation, with glycolysis providing a smaller amount of ATP production. This...
3.
Wong A, Sun Q, Latif I, Karwi Q
Mol Cell Biochem
. 2024 Aug;
480(3):1763-1783.
PMID: 39198360
In a rapidly expanding body of literature, the major role of energy metabolism in determining the response and polarization status of macrophages has been examined, and it is currently a...
4.
Abdualkader A, Karwi Q, Lopaschuk G, Al Batran R
J Pharm Pharm Sci
. 2024 Jul;
27:13040.
PMID: 39007094
Elevated levels of circulating branched-chain amino acids (BCAAs) and their associated metabolites have been strongly linked to insulin resistance and type 2 diabetes. Despite extensive research, the precise mechanisms linking...
5.
Wong A, Sun Q, Latif I, Karwi Q
J Pharm Pharm Sci
. 2024 Jul;
27:13210.
PMID: 38988822
Recent literature extensively investigates the crucial role of energy metabolism in determining the inflammatory response and polarization status of macrophages. This rapidly expanding area of research highlights the importance of...
6.
Ho K, Karwi Q, Wang F, Wagg C, Zhang L, Panidarapu S, et al.
Cardiovasc Res
. 2024 May;
120(10):1126-1137.
PMID: 38691671
Aims: Cardiac energy metabolism is perturbed in ischaemic heart failure and is characterized by a shift from mitochondrial oxidative metabolism to glycolysis. Notably, the failing heart relies more on ketones...
7.
Pherwani S, Connolly D, Sun Q, Karwi Q, Carr M, Ho K, et al.
Metabolism
. 2024 Feb;
154:155818.
PMID: 38369056
Background: Cardiac glucose oxidation is decreased in heart failure with reduced ejection fraction (HFrEF), contributing to a decrease in myocardial ATP production. In contrast, circulating ketones and cardiac ketone oxidation...
8.
Ketema E, Ahsan M, Zhang L, Karwi Q, Lopaschuk G
Sci Rep
. 2024 Jan;
14(1):1193.
PMID: 38216627
High rates of cardiac fatty acid oxidation during reperfusion of ischemic hearts contribute to contractile dysfunction. This study aimed to investigate whether lysine acetylation affects fatty acid oxidation rates and...
9.
Sun Q, Guven B, Wagg C, Almeida de Oliveira A, Silver H, Zhang L, et al.
Cardiovasc Res
. 2024 Jan;
120(4):360-371.
PMID: 38193548
Aims: Heart failure with preserved ejection fraction (HFpEF) is a prevalent disease worldwide. While it is well established that alterations of cardiac energy metabolism contribute to cardiovascular pathology, the precise...
10.
Gopal K, Abdualkader A, Li X, Greenwell A, Karwi Q, Altamimi T, et al.
J Biol Chem
. 2023 Oct;
299(12):105375.
PMID: 37865313
Pyruvate dehydrogenase (PDH) is the rate-limiting enzyme for glucose oxidation that links glycolysis-derived pyruvate with the tricarboxylic acid (TCA) cycle. Although skeletal muscle is a significant site for glucose oxidation...