Author: Qiu-Ye Wu | MedLuna.com

1.

Resolving the α-glycosidic linkage of arginine-rhamnosylated translation elongation factor P triggers generation of the first Arg specific antibody

Li X, Krafczyk R, Macosek J, Li Y, Zou Y, Simon B, et al.

Chem Sci . 2017 Apr; 7(12):6995-7001. PMID: 28451135

A previously discovered posttranslational modification strategy - arginine rhamnosylation - is essential for elongation factor P (EF-P) dependent rescue of polyproline stalled ribosomes in clinically relevant species such as and...

2.

WM130 preferentially inhibits hepatic cancer stem-like cells by suppressing AKT/GSK3β/β-catenin signaling pathway

Ni C, Qi Y, Zhang J, Liu Y, Xu W, Xu J, et al.

Oncotarget . 2016 Oct; 7(48):79544-79556. PMID: 27783993

The eradication of cancer stem cells (CSCs) is significant for cancer therapy and prevention. In this study, we evaluated WM130, a novel derivative of matrine, for its effect on CSCs...

3.

Bioactive compound reveals a novel function for ribosomal protein S5 in hepatic stellate cell activation and hepatic fibrosis

Xu W, Hu H, Tian Y, Wang S, Li J, Li J, et al.

Hepatology . 2014 Mar; 60(2):648-60. PMID: 24668691

Unlabelled: Liver fibrosis and its endstage, cirrhosis, represent a major public health problem worldwide. Activation of hepatic stellate cells (HSCs) is a central event in hepatic fibrosis. However, the proteins...

4.

Two novel innovanoside dimers from Daphne aurantiaca and a concise total synthesis of diinnovanoside A

Liang S, Liu S, Jin H, Shan L, Yu S, Shen Y, et al.

Chem Commun (Camb) . 2013 May; 49(62):6968-70. PMID: 23687654

Chemical examination of the methanolic extract from the stem bark of Daphne aurantiaca led to the isolation of two innovanoside dimers (1 and 2) with an unusual four-membered cyclobutane ring,...

5.

Spirolactonized Si-rhodamine: a novel NIR fluorophore utilized as a platform to construct Si-rhodamine-based probes

Wang T, Zhao Q, Hu H, Yu S, Liu X, Liu L, et al.

Chem Commun (Camb) . 2012 Jul; 48(70):8781-3. PMID: 22836301

Spirolactonized Si-rhodamine was prepared as a platform to construct Si-rhodamine-based probes by following the design strategy widely used in rhodamine systems. Among them, the reaction-based probe SiR-Hg was operated for...

6.

(6aS,11aR,11cS)-8-Sulfanylidene-2,3,5,6,6a,7,11,11a,11b,11c-decahydro-3a,7a-diaza-1H,4H-benzo[de]anthracen-3a-ium chloride hemihydrate

Wang L, Zhang C, Guo J, Wu Q, Hu H

Acta Crystallogr Sect E Struct Rep Online . 2011 Aug; 67(Pt 7):o1743-4. PMID: 21837131

The title compound, C(15)H(23)N(2)S(+)·Cl(-)·0.5H(2)O, was prepared from (6aS,11aR,11cS)-2,3,5,6,6a,7,11,11a,11b,11c-deca-hydro-3a,7a-diaza-1H,4H-benzo[de]anthracene-8-one (sophocarpine) and Lawesson's reagent. The thione-substituted ring is in an envelope conformation and the three other six-membered rings are in chair conformations....

7.

Enhanced interferon-gamma secretion and antitumor activity of T-lymphocytes activated by dendritic cells loaded with glycoengineered myeloma antigens

Xiong H, Wu Q, Hu H, Liu B, Guo Z, Sze D, et al.

Chin Med J (Engl) . 2007 Oct; 120(19):1678-84. PMID: 17935669

Background: Immunotherapy is emerging as a promising cure for cancer. However, a severe problem in this area is the immune tolerance to tumor cells and tumor-associated antigens, as evidenced by...

8.

Design, synthesis, and antifungal activities of novel 1H-triazole derivatives based on the structure of the active site of fungal lanosterol 14 alpha-demethylase (CYP51)

Zhao Q, Hu H, Li Y, Song Y, Cai L, Wu Q, et al.

Chem Biodivers . 2007 Jul; 4(7):1472-9. PMID: 17638327

A series of fluconazole (1) analogues, compounds 3a-k, were prepared as potential antifungal agents. They were designed by computational docking experiments to the active site of the cytochrome P450 14alpha-sterol...

9.

Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51)

Sun Q, Xu J, Cao Y, Zhang W, Wu Q, Zhang D, et al.

Eur J Med Chem . 2007 Mar; 42(9):1226-33. PMID: 17335940

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols have been designed and synthesized on the basis of the structure-activity relationships and antimycotic mechanism of azole antifungal agents. Their structures were confirmed by elemental analysis,...

10.

Synthesis and evaluation of novel 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols as antifungal agents

Sun Q, Zhang W, Xu J, Cao Y, Wu Q, Zhang D, et al.

Eur J Med Chem . 2006 Dec; 42(8):1151-7. PMID: 17184885

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-[(4-substitutedphenyl)-piperazin-1-yl]-propan-2-ols have been designed and synthesized on the basis of the structure-activity relationships and antimycotic mechanism of azole antifungal agents. Their structures were confirmed by elemental analysis,...