Qingding Wang
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Explore the profile of Qingding Wang including associated specialties, affiliations and a list of published articles.
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34
Citations
748
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Recent Articles
11.
Li C, Zhou Y, Kim J, Sengoku T, Alstott M, Weiss H, et al.
Biochim Biophys Acta Mol Cell Res
. 2021 Jan;
1868(4):118966.
PMID: 33450304
Activation of the Wnt/β-catenin pathway is one of the hallmarks of colorectal cancer (CRC). Sirtuin 2 (SIRT2) protein has been shown to inhibit CRC proliferation. Previously, we reported that SIRT2...
12.
Li C, Zhou Y, Rychahou P, Weiss H, Lee E, Perry C, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Jan;
10(1):43-57.
PMID: 31954883
Background And Aims: Intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. Disruption of this homeostasis is associated with disorders such as inflammatory bowel disease (IBD). We investigated...
13.
Kim J, Li C, Weiss H, Zhou Y, Liu C, Wang Q, et al.
Cells
. 2019 Sep;
8(9).
PMID: 31546785
The Wnt/β-catenin pathway plays a crucial role in development and renewal of the intestinal epithelium. Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), a rate-limiting ketogenic enzyme in the synthesis of ketone body...
14.
Wang Q, Zhou Y, Rychahou P, Harris J, Zaytseva Y, Liu J, et al.
Cancer Res
. 2018 Apr;
78(12):3163-3175.
PMID: 29666061
Activation of the Wnt/β-catenin signaling pathway drives colorectal cancer growth by deregulating expression of downstream target genes, including the proto-oncogene. The critical targets that mediate the functions of oncogenic c-Myc...
15.
Wang Q, Zhou Y, Rychahou P, W-M Fan T, Lane A, Weiss H, et al.
Cell Death Differ
. 2016 Dec;
24(3):458-468.
PMID: 27935584
The intestinal epithelium undergoes a continual process of proliferation, differentiation and apoptosis. Previously, we have shown that the PI3K/Akt/mTOR pathway has a critical role in intestinal homeostasis. However, the downstream...
16.
Zhou Y, Wang Q, Weiss H, Evers B
Mol Biol Cell
. 2014 Jul;
25(18):2882-90.
PMID: 25057011
The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis that is regulated by multiple signaling pathways. Previously, we have shown that the nuclear factor of activated T-cells...
17.
Zhou Y, Wang Q, Guo Z, Weiss H, Evers B
Mol Biol Cell
. 2012 Jun;
23(15):2963-72.
PMID: 22696685
The nuclear factor of activated T-cell (NFAT) proteins are a family of transcription factors (NFATc1-c4) involved in the regulation of cell differentiation. We identified REDD1, a negative regulator of mammalian...
18.
Guo Z, Zhou Y, Evers B, Wang Q
Biochem Biophys Res Commun
. 2012 Jan;
418(2):426-32.
PMID: 22285861
Rictor (Rapamycin-insensitive companion of mTOR) forms a complex with mTOR and phosphorylates and activates Akt. Activation of Akt induces expression of c-Myc and cyclin E, which are overexpressed in colorectal...
19.
Wang Q, Zhou Y, Weiss H, Chow C, Evers B
PLoS One
. 2011 May;
6(5):e19882.
PMID: 21603612
TNF-related apoptosis-inducing ligand (TRAIL; Apo2) has been shown to promote intestinal cell differentiation. Nuclear factor of activated T cells (NFAT) participates in the regulation of a variety of cellular processes,...
20.
Wang Q, Zhou Y, Jackson L, Johnson S, Chow C, Evers B
Mol Biol Cell
. 2010 Dec;
22(3):412-20.
PMID: 21148296
The nuclear factor of activated T cell (NFAT) proteins are a family of transcription factors (NFATc1-c4) involved in the regulation of cell differentiation and adaptation. Previously we demonstrated that inhibition...