Q Richard Lu
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Explore the profile of Q Richard Lu including associated specialties, affiliations and a list of published articles.
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133
Citations
5833
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Recent Articles
11.
Liu X, Xin D, Zhong X, Zhao C, Li Z, Zhang L, et al.
Cell
. 2024 May;
187(10):2465-2484.e22.
PMID: 38701782
Remyelination failure in diseases like multiple sclerosis (MS) was thought to involve suppressed maturation of oligodendrocyte precursors; however, oligodendrocytes are present in MS lesions yet lack myelin production. We found...
12.
Schmidt A, Kremp M, Aratake T, Cui S, Lin Y, Zhong X, et al.
Glia
. 2024 Mar;
72(7):1304-1318.
PMID: 38546197
Oligodendrocyte differentiation and myelination in the central nervous system are controlled and coordinated by a complex gene regulatory network that contains several transcription factors, including Zfp488 and Nkx2.2. Despite the...
13.
Koschmann C, Al-Holou W, Alonso M, Anastas J, Bandopadhayay P, Barron T, et al.
Cancer Cell
. 2023 Dec;
42(1):1-5.
PMID: 38039965
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise. We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include...
14.
Xin D, Liao Y, Rao R, Ogurek S, Sengupta S, Xin M, et al.
Neuro Oncol
. 2023 Nov;
26(4):735-748.
PMID: 38011799
Background: Diffuse intrinsic pontine gliomas (DIPG/DMG) are devastating pediatric brain tumors with extraordinarily limited treatment options and uniformly fatal prognosis. Histone H3K27M mutation is a common recurrent alteration in DIPG...
15.
Talley M, Nardini D, Ehrman L, Lu Q, Waclaw R
Neural Dev
. 2023 Sep;
18(1):5.
PMID: 37684687
Background: E-proteins encoded by Tcf3, Tcf4, and Tcf12 are class I basic helix-loop-helix (bHLH) transcription factors (TFs) that are thought to be widely expressed during development. However, their function in...
16.
Fan C, Wunderlich M, Cai X, Yan Z, Zhang F, Davis A, et al.
Leukemia
. 2023 Aug;
37(10):2073-2081.
PMID: 37532788
mTOR, as a serine/threonine kinase, is a widely pursued anticancer target. Multiple clinical trials of mTOR kinase inhibitors are ongoing, but their specificity and safety features remain lacking. Here, we...
17.
Garrett M, Albano R, Carnwath T, Elahi L, Behrmann C, Pemberton M, et al.
Sci Rep
. 2023 Aug;
13(1):12433.
PMID: 37528157
Low-grade and secondary high-grade gliomas frequently contain mutations in the IDH1 or IDH2 metabolic enzymes that are hypothesized to drive tumorigenesis by inhibiting many of the chromatin-regulating enzymes that regulate...
18.
Thompson M, Sakabe M, Verba M, Hao J, Meadows S, Lu Q, et al.
Front Physiol
. 2023 Jun;
14:1165379.
PMID: 37324380
Proper vascular formation is regulated by multiple signaling pathways. The vascular endothelial growth factor (VEGF) signaling promotes endothelial proliferation. Notch and its downstream targets act to lead endothelial cells toward...
19.
Luo Z, Xin D, Liao Y, Berry K, Ogurek S, Zhang F, et al.
Nat Commun
. 2023 Feb;
14(1):762.
PMID: 36765089
MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the molecular and genetic events triggering MYC amplification and malignant transformation remain elusive. Here we report that mutations in CTDNEP1, a...
20.
Hu X, Wu X, Berry K, Zhao C, Xin D, Ogurek S, et al.
Nat Cell Biol
. 2023 Feb;
25(2):323-336.
PMID: 36732631
Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial ependymoma development. Here, unexpectedly, we find that liquid-liquid phase separation, rather than nuclear localization, of recurrent patient-derived YAP fusions,...