Pyry I Toivanen
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Explore the profile of Pyry I Toivanen including associated specialties, affiliations and a list of published articles.
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109
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Recent Articles
1.
Mallick R, Gurzeler E, Toivanen P, Nieminen T, Yla-Herttuala S
Front Bioeng Biotechnol
. 2022 Aug;
10:907538.
PMID: 35992336
Previous studies have indicated that vascular endothelial growth factor B186 (VEGF-B186) supports coronary vascular growth in normal and ischemic myocardium. However, previous studies also indicated that induction of ventricular arrhythmias...
2.
Jauhiainen S, Laakkonen J, Ketola K, Toivanen P, Nieminen T, Ninchoji T, et al.
Front Physiol
. 2019 Apr;
10:224.
PMID: 30930791
Vascular endothelial growth factors (VEGFs) are key mediators of endothelial cell (EC) function in angiogenesis. Emerging knowledge also supports the involvement of axon guidance-related factors in the regulation of angiogenesis...
3.
Toivanen P, Nieminen T, Laakkonen J, Heikura T, Kaikkonen M, Yla-Herttuala S
Sci Rep
. 2017 Jul;
7(1):5525.
PMID: 28717175
Vascular Endothelial Growth Factors (VEGFs) are promising molecules for the treatment of ischemic diseases by pro-angiogenic therapy. Snake venom VEGFs are a novel subgroup with unique receptor binding profiles and...
4.
Laakkonen J, Lappalainen J, Theelen T, Toivanen P, Nieminen T, Jauhiainen S, et al.
Angiogenesis
. 2016 Nov;
20(1):109-124.
PMID: 27873103
Aims: Histamine and vascular endothelial growth factor A (VEGF) are central regulators in vascular pathologies. Their gene regulation leading to vascular remodeling has remained obscure. In this study, EC regulation...
5.
Slit2 modifies VEGF-induced angiogenic responses in rabbit skeletal muscle via reduced eNOS activity
Nieminen T, Toivanen P, Laakkonen J, Heikura T, Kaikkonen M, Airenne K, et al.
Cardiovasc Res
. 2015 May;
107(2):267-76.
PMID: 26002231
Aims: Slit2 is a possible modulator of VEGF-induced angiogenesis, but its effects have not been tested on large animal models. We studied the effect of Slit2 on therapeutic angiogenesis induced...
6.
Nieminen T, Toivanen P, Rintanen N, Heikura T, Jauhiainen S, Airenne K, et al.
Biochim Biophys Acta
. 2013 Oct;
1840(1):454-63.
PMID: 24112971
Background: Vascular endothelial growth factors (VEGFs) are potential therapeutic agents for treatment of ischemic diseases. Their angiogenic effects are mainly mediated through VEGF receptor 2 (VEGFR2). Methods: Receptor binding, signaling,...
7.
Jauhiainen S, Hakkinen S, Toivanen P, Heinonen S, Jyrkkanen H, Kansanen E, et al.
Arterioscler Thromb Vasc Biol
. 2011 Apr;
31(7):1617-24.
PMID: 21474827
Objective: The mature form of human vascular endothelial growth factor-D (hVEGF-D(ΔNΔC)) is an efficient angiogenic factor, but its full mechanism of action has remained unclear. We studied the effects of...
8.
Karkkainen H, Lesch H, Maatta A, Toivanen P, Mahonen A, Roschier M, et al.
BMC Res Notes
. 2009 Apr;
2:63.
PMID: 19389242
Background: Baculovirus expression vector system (BEVS) has become a standard in recombinant protein production and virus-like particle preparation for numerous applications. Findings: We describe here protocols which adapt baculovirus generation...
9.
Toivanen P, Nieminen T, Viitanen L, Alitalo A, Roschier M, Jauhiainen S, et al.
J Biol Chem
. 2009 Apr;
284(23):16037-48.
PMID: 19366703
Members of the vascular endothelial growth factor (VEGF) family play a pivotal role in angiogenesis and lymphangiogenesis. They are potential therapeutics to induce blood vessel formation in myocardium and skeletal...
10.
Laitinen O, Airenne K, Hytonen V, Peltomaa E, Mahonen A, Wirth T, et al.
Nucleic Acids Res
. 2005 Feb;
33(4):e42.
PMID: 15731335
We have constructed a novel tetra-promoter vector (pBVboostFG) system that enables screening of gene/cDNA libraries for functional genomic studies. The vector enables an all-in-one strategy for gene expression in mammalian,...