Pyry Helkkula
Overview
Explore the profile of Pyry Helkkula including associated specialties, affiliations and a list of published articles.
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5
Citations
43
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Recent Articles
1.
Kiiskinen T, Helkkula P, Krebs K, Karjalainen J, Saarentaus E, Mars N, et al.
Nat Med
. 2023 Jan;
29(1):209-218.
PMID: 36653479
Little is known about the genetic determinants of medication use in preventing cardiometabolic diseases. Using the Finnish nationwide drug purchase registry with follow-up since 1995, we performed genome-wide association analyses...
2.
Helkkula P, Hassan S, Saarentaus E, Vartiainen E, Ruotsalainen S, Leinonen J, et al.
Commun Biol
. 2023 Jan;
6(1):71.
PMID: 36653477
Varicose veins is the most common manifestation of chronic venous disease that displays female-biased incidence. To identify protein-inactivating variants that could guide identification of drug target genes for varicose veins...
3.
Marabita F, James T, Karhu A, Virtanen H, Kettunen K, Stenlund H, et al.
Cell Syst
. 2021 Dec;
13(3):241-255.e7.
PMID: 34856119
We explored opportunities for personalized and predictive health care by collecting serial clinical measurements, health surveys, genomics, proteomics, autoantibodies, metabolomics, and gut microbiome data from 96 individuals who participated in...
4.
Helkkula P, Kiiskinen T, Havulinna A, Karjalainen J, Koskinen S, Salomaa V, et al.
PLoS Genet
. 2021 Apr;
17(4):e1009501.
PMID: 33909604
Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs that were associated with both lipid levels and the risk...
5.
Bass C, Helkkula P, de Paola V, Clopath C, Bharath A
PLoS One
. 2017 Sep;
12(9):e0183309.
PMID: 28873436
Studies of structural plasticity in the brain often require the detection and analysis of axonal synapses (boutons). To date, bouton detection has been largely manual or semi-automated, relying on a...