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» Authors » Purna Chaitanya Konduri

Purna Chaitanya Konduri

Explore the profile of Purna Chaitanya Konduri including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 113
Followers 0
Related Specialties
Oncology
Cell Biology
Biochemistry
Top 10 Co-Authors
Li Zhang
Sanchareeka Dey
Poorva Ghosh
Sarada Preeta Kalainayakan
Tianyuan Wang
Adnin Ashrafi
Narges Salamat
Chantal Vidal
Sagar Sohoni
Keely E Fitzgerald
Published In
Cancer Res
Cell Biosci
Cells
Sci Rep
Mol Cancer Ther
Affiliations
Soon will be listed here.
Recent Articles
1.
Heme Sequestration Effectively Suppresses the Development and Progression of Both Lung Adenocarcinoma and Squamous Cell Carcinoma
Dey S, Ashrafi A, Vidal C, Jain N, Kalainayakan S, Ghosh P, et al.
Mol Cancer Res . 2021 Oct; 20(1):139-149. PMID: 34635508
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two most common subtypes of lung cancer. Here, to identify new, targetable molecular properties of both subtypes, we monitored changes in...
2.
Heme Sequestration as an Effective Strategy for the Suppression of Tumor Growth and Progression
Wang T, Ashrafi A, Konduri P, Ghosh P, Dey S, Modareszadeh P, et al.
Mol Cancer Ther . 2021 Sep; 20(12):2506-2518. PMID: 34552010
Heme is an essential nutritional, metabolic, and signaling molecule in living organisms. Pathogenic microbes extract heme from hosts to obtain metallonutrient, while heme fuels mitochondrial respiration and ATP generation in...
3.
Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation
Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, et al.
Cancer Res . 2020 Jun; 80(17):3542-3555. PMID: 32546631
Multispectral optoacoustic tomography (MSOT) is an emerging noninvasive imaging modality that can detect real-time dynamic information about the tumor microenvironment in humans and animals. Oxygen enhanced (OE)-MSOT can monitor tumor...
4.
Heme, A Metabolic Sensor, Directly Regulates the Activity of the KDM4 Histone Demethylase Family and Their Interactions with Partner Proteins
Konduri P, Wang T, Salamat N, Zhang L
Cells . 2020 Apr; 9(3). PMID: 32235736
The KDM4 histone demethylase subfamily is constituted of yeast JmjC domain-containing proteins, such as Gis1, and human Gis1 orthologues, such as KDM4A/B/C. KDM4 proteins have important functions in regulating chromatin...
5.
Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells
Sohoni S, Ghosh P, Wang T, Kalainayakan S, Vidal C, Dey S, et al.
Cancer Res . 2019 Mar; 79(10):2511-2525. PMID: 30902795
Tumors of human non-small cell lung cancer (NSCLC) are heterogeneous but exhibit elevated glycolysis and glucose oxidation relative to benign lung tissues. Heme is a central molecule for oxidative metabolism...
6.
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression
Kalainayakan S, Ghosh P, Dey S, Fitzgerald K, Sohoni S, Konduri P, et al.
Sci Rep . 2019 Feb; 9(1):1405. PMID: 30723259
Lung cancer remains the leading cause of cancer-related death, despite the advent of targeted therapies and immunotherapies. Therefore, it is crucial to identify novel molecular features unique to lung tumors....
7.
Essential roles of mitochondrial and heme function in lung cancer bioenergetics and tumorigenesis
Kalainayakan S, Fitzgerald K, Konduri P, Vidal C, Zhang L
Cell Biosci . 2018 Nov; 8:56. PMID: 30410721
Contrary to Warburg's hypothesis, mitochondrial oxidative phosphorylation (OXPHOS) contributes significantly to fueling cancer cells. Several recent studies have demonstrated that radiotherapy-resistant and chemotherapy-resistant cancer cells depend on OXPHOS for survival...