Pulkit Gupta
Overview
Explore the profile of Pulkit Gupta including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
329
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Recent Articles
11.
Hernandez L, Kroh H, Hsieh E, Yang X, Beaumont M, Sheth P, et al.
J Mol Biol
. 2017 Feb;
429(7):1030-1044.
PMID: 28232034
The exotoxins toxin A (TcdA) and toxin B (TcdB) are produced by the bacterial pathogen Clostridium difficile and are responsible for the pathology associated with C. difficile infection (CDI). The...
12.
Vohra V, Gupta P, Malik P, Pathak A
Oman J Ophthalmol
. 2016 Feb;
8(3):191-3.
PMID: 26903730
Capillary hemangioma is one the most common tumors of eyelid and orbit reported in pediatric age group. Oral propranolol therapy is latest addition to the armamentarium of treatment options available...
13.
Gupta P, Liu B, Klepacki D, Gupta V, Schulten K, Mankin A, et al.
Nat Chem Biol
. 2016 Jan;
12(3):153-8.
PMID: 26727240
Regulation of gene expression in response to the changing environment is critical for cell survival. For instance, binding of macrolide antibiotics to the ribosome promotes translation arrest at the leader...
14.
Tam J, Beilhartz G, Auger A, Gupta P, Therien A, Melnyk R
Chem Biol
. 2015 Jan;
22(2):175-85.
PMID: 25619932
Clostridium difficile causes life-threatening diarrhea through the actions of its homologous toxins TcdA and TcdB on human colonocytes. Therapeutic agents that block toxin-induced damage are urgently needed to prevent the...
15.
Polikanov Y, Szal T, Jiang F, Gupta P, Matsuda R, Shiozuka M, et al.
Mol Cell
. 2014 Oct;
56(4):541-50.
PMID: 25306922
Negamycin (NEG) is a ribosome-targeting antibiotic that exhibits clinically promising activity. Its binding site and mode of action have remained unknown. We solved the structure of the Thermus thermophilus ribosome...
16.
Arenz S, Ramu H, Gupta P, Berninghausen O, Beckmann R, Vazquez-Laslop N, et al.
Nat Commun
. 2014 Mar;
5:3501.
PMID: 24662426
In bacteria, ribosome stalling during translation of ErmBL leader peptide occurs in the presence of the antibiotic erythromycin and leads to induction of expression of the downstream macrolide resistance methyltransferase...
17.
Gupta P, Malik P, Gupta H
Oman J Ophthalmol
. 2014 Jan;
6(3):211.
PMID: 24379562
No abstract available.
18.
Gupta P, Kannan K, Mankin A, Vazquez-Laslop N
Mol Cell
. 2013 Nov;
52(5):629-42.
PMID: 24239289
The expression of many genes is controlled by upstream ORFs (uORFs). Typically, the progression of the ribosome through a regulatory uORF, which depends on the physiological state of the cell,...
19.
Gupta P, Sothiselvam S, Vazquez-Laslop N, Mankin A
Nat Commun
. 2013 Jun;
4:1984.
PMID: 23749080
A key mechanism of bacterial resistance to macrolide antibiotics is the dimethylation of a nucleotide in the large ribosomal subunit by erythromycin resistance methyltransferases. The majority of erm genes are...
20.
Gupta P, Mahesh B, Gupta H
Indian J Ophthalmol
. 2013 Apr;
61(6):311.
PMID: 23619492
No abstract available.