Priyadharshini Devarajan
Overview
Explore the profile of Priyadharshini Devarajan including associated specialties, affiliations and a list of published articles.
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24
Citations
366
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Recent Articles
11.
Devarajan P, Swain S
Cell Host Microbe
. 2019 Mar;
25(3):354-355.
PMID: 30870620
In this issue of Cell Host & Microbe, two articles (Lee et al., 2019; Henry et al., 2019) find the influenza-specific antibody repertoire in humans becomes static over time and...
12.
Devarajan P, Jones M, Kugler-Umana O, Vong A, Xia J, Swain S
Front Immunol
. 2018 Apr;
9:596.
PMID: 29632538
Although much is known about the mechanisms by which pathogen recognition drives the initiation of T cell responses, including those to respiratory viruses, the role of pathogen recognition in fate...
13.
Miska J, Lui J, Toomer K, Devarajan P, Cai X, Houghton J, et al.
J Exp Med
. 2018 Jan;
215(3):841-858.
PMID: 29374027
Genetically predisposed CTLA4 insufficiency in humans is associated with gastric cancer development, which is paradoxical to the prototypical role of CTLA4 in suppressing antitumor immunity. CTLA4 is a critical immune...
14.
Brahmakshatriya V, Kuang Y, Devarajan P, Xia J, Zhang W, Vong A, et al.
J Immunol
. 2017 Mar;
198(7):2819-2833.
PMID: 28250157
Naive CD4 T cell responses, especially their ability to help B cell responses, become compromised with aging. We find that using APC pretreated ex vivo with TLR agonists, polyinosinic-polycytidylic acid...
15.
Marshall N, Vong A, Devarajan P, Brauner M, Kuang Y, Nayar R, et al.
J Immunol
. 2016 Dec;
198(3):1142-1155.
PMID: 28031335
CD4 T cells can differentiate into multiple effector subsets, including ThCTL that mediate MHC class II-restricted cytotoxicity. Although CD4 T cell-mediated cytotoxicity has been reported in multiple viral infections, their...
16.
Bautista B, Devarajan P, McKinstry K, Strutt T, Vong A, Jones M, et al.
J Immunol
. 2016 Nov;
197(10):3936-3949.
PMID: 27798159
Although memory CD4 T cells are critical for effective immunity to pathogens, the mechanisms underlying their generation are still poorly defined. We find that following murine influenza infection, most effector...
17.
Devarajan P, Bautista B, Vong A, McKinstry K, Strutt T, Swain S
Front Immunol
. 2016 May;
7:136.
PMID: 27148257
Influenza viral evolution presents a formidable challenge to vaccination due to the virus' ability to rapidly mutate to evade immune responses. Live influenza infections generate large and diverse CD4 effector...
18.
Lui J, Devarajan P, Teplicki S, Chen Z
Cell Rep
. 2015 Feb;
10(4):574-85.
PMID: 25640181
CD4 and CD8 T cell lineages differentiate through respective thymic selection processes. Here, we report cross-differentiation from the CD8 lineage to CD4 T cells, but not vice versa, predominantly in...
19.
Devarajan P, Miska J, Lui J, Swieboda D, Chen Z
J Immunol
. 2014 Sep;
193(9):4368-80.
PMID: 25246499
Quantitative variations in CTLA4 expression, because of genetic polymorphisms, are associated with various human autoimmune conditions, including type 1 diabetes (T1D). Extensive studies have demonstrated that CTLA4 is not only...
20.
Miska J, Abdulreda M, Devarajan P, Lui J, Suzuki J, Pileggi A, et al.
J Exp Med
. 2014 Feb;
211(3):441-56.
PMID: 24567447
Real-time imaging studies are reshaping immunological paradigms, but a visual framework is lacking for self-antigen-specific T cells at the effector phase in target tissues. To address this issue, we conducted...