Prem S Subramaniam
Overview
Explore the profile of Prem S Subramaniam including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
570
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0
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Recent Articles
1.
Rosenberger G, Li W, Turunen M, He J, Subramaniam P, Pampou S, et al.
Nat Commun
. 2024 May;
15(1):3909.
PMID: 38724493
Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling...
2.
Rosenberger G, Li W, Turunen M, He J, Subramaniam P, Pampou S, et al.
bioRxiv
. 2023 Feb;
PMID: 36824919
Aberrant signaling pathway activity is a hallmark of tumorigenesis and progression, which has guided targeted inhibitor design for over 30 years. Yet, adaptive resistance mechanisms, induced by rapid, context-specific signaling...
3.
Paull E, Aytes A, Jones S, Subramaniam P, Giorgi F, Douglass E, et al.
Cell
. 2021 Jan;
184(2):334-351.e20.
PMID: 33434495
Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins...
4.
Alvarez M, Subramaniam P, Tang L, Grunn A, Aburi M, Rieckhof G, et al.
Nat Genet
. 2018 Jun;
50(7):979-989.
PMID: 29915428
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their...
5.
Westphalen C, Takemoto Y, Tanaka T, Macchini M, Jiang Z, Renz B, et al.
Cell Stem Cell
. 2016 Apr;
18(4):441-55.
PMID: 27058937
The existence of adult pancreatic progenitor cells has been debated. While some favor the concept of facultative progenitors involved in homeostasis and repair, neither a location nor markers for such...
6.
Subramaniam P, Whye D, Efimenko E, Chen J, Tosello V, De Keersmaecker K, et al.
Cancer Cell
. 2012 Apr;
21(4):459-72.
PMID: 22516257
Constitutive phosphoinositide 3-kinase (PI3K)/Akt activation is common in T cell acute lymphoblastic leukemia (T-ALL). Although four distinct class I PI3K isoforms (α, β, γ, δ) could participate in T-ALL pathogenesis,...
7.
Fulcher A, Ahmed C, Noon-Song E, Kwan R, Subramaniam P, Johnson H, et al.
FEBS Lett
. 2008 Apr;
582(11):1569-74.
PMID: 18405666
Interferon (IFN) gamma's ability to localise in the nucleus and function in gene activation has been known for some time, although the role of the conventional nuclear transporting importin molecules...
8.
Ahmed C, Burkhart M, Subramaniam P, Mujtaba M, Johnson H
J Virol
. 2005 Apr;
79(9):5632-9.
PMID: 15827178
We have developed peptide mimetics of gamma interferon (IFN-gamma) that play a direct role in the activation and nuclear translocation of STAT1alpha transcription factor. These mimetics do not act through...
9.
Flowers L, Subramaniam P, Johnson H
Oncogene
. 2005 Feb;
24(12):2114-20.
PMID: 15688010
Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic...
10.
Subramaniam P, Johnson H
FEBS Lett
. 2004 Dec;
578(3):207-10.
PMID: 15589821
A nuclear localization sequence (NLS) in the type II interferon (IFN) IFN gamma, which is responsible for the nuclear translocation of both the ligand and the alpha-subunit (IFNGR1) of the...