Lawrence O Flowers
Overview
Explore the profile of Lawrence O Flowers including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
223
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Recent Articles
1.
Waiboci L, Ahmed C, Mujtaba M, Flowers L, Martin J, Haider M, et al.
J Immunol
. 2007 Apr;
178(8):5058-68.
PMID: 17404288
Suppressor of cytokine signaling (SOCS)-1 protein modulates signaling by IFN-gamma by binding to the autophosphorylation site of JAK2 and by targeting bound JAK2 to the proteosome for degradation. We have...
2.
Mujtaba M, Patel C, Patel R, Flowers L, Burkhart M, Waiboci L, et al.
Clin Vaccine Immunol
. 2006 Aug;
13(8):944-52.
PMID: 16893996
We have demonstrated previously that the C-terminal gamma interferon (IFN-gamma) mimetic peptide consisting of residues 95 to 133 [IFN-gamma(95-133)], which contains the crucial IFN-gamma nuclear localization sequence (NLS), has antiviral...
3.
Mujtaba M, Flowers L, Patel C, Patel R, Haider M, Johnson H
J Immunol
. 2005 Oct;
175(8):5077-86.
PMID: 16210611
We have previously characterized a novel tyrosine kinase inhibitor peptide (Tkip) that is a mimetic of suppressor of cytokine signaling 1 (SOCS-1) and inhibits JAK2 phosphorylation of the transcription factor...
4.
Flowers L, Subramaniam P, Johnson H
Oncogene
. 2005 Feb;
24(12):2114-20.
PMID: 15688010
Prostate cancer is the second highest cause of cancer-related deaths of men in the US. Signal transducers and activators of transcription (STATs) proteins are a small family of latent cytoplasmic...
5.
Flowers L, Johnson H, Mujtaba M, Ellis M, Haider S, Subramaniam P
J Immunol
. 2004 Jun;
172(12):7510-8.
PMID: 15187130
Positive and negative regulation of cytokines such as IFN-gamma are key to normal homeostatic function. Negative regulation of IFN-gamma in cells occurs via proteins called suppressors of cytokine signaling (SOCS)1...
6.
Subramaniam P, Flowers L, Haider S, Johnson H
Biochemistry
. 2004 May;
43(18):5445-54.
PMID: 15122910
The C-terminus of interferon-gamma (IFNgamma) contains a nuclear localization sequence (NLS) required for the activation and nuclear translocation of the transcription factor STAT1alpha and induction of IFNgamma-activated genes. On the...