Prem S Kaushal
Overview
Explore the profile of Prem S Kaushal including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
137
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Recent Articles
1.
Kumar N, Sharma S, Kaushal P
Nat Commun
. 2024 Jan;
15(1):638.
PMID: 38245551
Ribosome hibernation is a key survival strategy bacteria adopt under environmental stress, where a protein, hibernation promotion factor (HPF), transitorily inactivates the ribosome. Mycobacterium tuberculosis encounters hypoxia (low oxygen) as...
2.
Prajapat S, Mishra L, Khera S, Owusu S, Ahuja K, Sharma P, et al.
EMBO Mol Med
. 2024 Jan;
16(1):185-217.
PMID: 38177535
Japanese encephalitis virus (JEV) pathogenesis is driven by a combination of neuronal death and neuroinflammation. We tested 42 FDA-approved drugs that were shown to induce autophagy for antiviral effects. Four...
3.
Pal P, Khan M, Sharma S, Kumar Y, Mangla N, Kaushal P, et al.
Commun Biol
. 2023 Jul;
6(1):708.
PMID: 37433855
Survival response of the human tuberculosis pathogen, Mycobacterium tuberculosis (Mtb) to a diverse environmental cues is governed through its versatile transcription regulatory mechanisms with the help of a large pool...
4.
Agarwal N, Sharma S, Pal P, Kaushal P, Kumar N
Microbiology (Reading)
. 2022 Aug;
168(8).
PMID: 35917161
Era GTPase is universally present in microbes including (Mtb) complex bacteria. While Era is known to regulate ribosomal assembly in and predicted to be essential for growth, its function in...
5.
Kumar N, Sharma S, Kaushal P
Mol Aspects Med
. 2021 Aug;
81:101002.
PMID: 34344520
Mycobacterium tuberculosis (Mtb) causes one of humankind's deadliest diseases, tuberculosis. Mtb protein synthesis machinery possesses several unique species-specific features, including its ribosome that carries two mycobacterial specific ribosomal proteins, bL37...
6.
Koripella R, Sharma M, Bhargava K, Datta P, Kaushal P, Keshavan P, et al.
Nat Commun
. 2020 Aug;
11(1):3830.
PMID: 32737313
The mammalian mitochondrial ribosome (mitoribosome) and its associated translational factors have evolved to accommodate greater participation of proteins in mitochondrial translation. Here we present the 2.68-3.96 Å cryo-EM structures of...
7.
Li Y, Sharma M, Koripella R, Yang Y, Kaushal P, Lin Q, et al.
Proc Natl Acad Sci U S A
. 2018 Jul;
115(32):8191-8196.
PMID: 30038002
Bacteria respond to zinc starvation by replacing ribosomal proteins that have the zinc-binding CXXC motif (C+) with their zinc-free (C-) paralogues. Consequences of this process beyond zinc homeostasis are unknown....
8.
Kaushal P, Sharma M, Agrawal R
Biochimie
. 2015 Mar;
114:119-26.
PMID: 25797916
Mitochondria carry their own genetic material and gene-expression machinery, including ribosomes, which are responsible for synthesizing polypeptides that form essential components of the complexes involved in oxidative phosphorylation (or ATP...
9.
Kaushal P, Sharma M, Booth T, Haque E, Tung C, Sanbonmatsu K, et al.
Proc Natl Acad Sci U S A
. 2014 May;
111(20):7284-9.
PMID: 24799711
The mammalian mitochondrial ribosomes (mitoribosomes) are responsible for synthesizing 13 membrane proteins that form essential components of the complexes involved in oxidative phosphorylation or ATP generation for the eukaryotic cell....