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Prateek Kulkarni

Explore the profile of Prateek Kulkarni including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 108
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Recent Articles
1.
Kulkarni P, Basu R, Bonn T, Low B, Mazurek N, Kopchick J
Cancers (Basel) . 2024 Aug; 16(15). PMID: 39123364
Drug resistance in melanoma is a major hindrance in cancer therapy. Growth hormone (GH) plays a pivotal role in contributing to the resistance to chemotherapy. Knocking down or blocking the...
2.
Basu R, Kulkarni P, Swegan D, Duran-Ortiz S, Ahmad A, Caggiano L, et al.
Int J Mol Sci . 2024 Jul; 25(13). PMID: 39000545
Chemotherapy treatment against pancreatic ductal adenocarcinoma (PDAC) is thwarted by tumoral activation of multiple therapy resistance pathways. The growth hormone (GH)-GH receptor (GHR) pair is a covert driver of multimodal...
3.
List E, Duran-Ortiz S, Kulkarni P, Davis E, Mora-Criollo P, Berryman D, et al.
Vitam Horm . 2023 Sep; 123:109-149. PMID: 37717983
Much of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by...
4.
Basu R, Brody R, Sandbhor U, Kulkarni P, Davis E, Swegan D, et al.
J Biol Chem . 2023 Jul; 299(8):105030. PMID: 37442239
Human growth hormone (hGH) is a pituitary-derived endocrine protein that regulates several critical postnatal physiologic processes including growth, organ development, and metabolism. Following adulthood, GH is also a regulator of...
5.
Basu R, Qian Y, Mathes S, Terry J, Arnett N, Riddell T, et al.
Front Oncol . 2022 Jul; 12:936145. PMID: 35865483
Knockdown of GH receptor (GHR) in melanoma cells downregulates ATP-binding cassette-containing (ABC) transporters and sensitizes them to anti-cancer drug treatments. Here we aimed to determine whether a GHR antagonist (GHRA)...
6.
Duran-Ortiz S, List E, Ikeno Y, Young J, Basu R, Bell S, et al.
Aging Cell . 2021 Nov; 20(12):e13506. PMID: 34811874
Studies in multiple species indicate that reducing growth hormone (GH) action enhances healthy lifespan. In fact, GH receptor knockout (GHRKO) mice hold the Methuselah prize for the world's longest-lived laboratory...
7.
Qian Y, Berryman D, Basu R, List E, Okada S, Young J, et al.
Pituitary . 2021 Nov; 25(1):1-51. PMID: 34797529
Much of our understanding of GH's action stems from animal models and the generation and characterization of genetically altered or modified mice. Manipulation of genes in the GH/IGF1 family in...
8.
Basu R, Nahar K, Kulkarni P, Kerekes O, Sattler M, Hall Z, et al.
J Biol Chem . 2021 Mar; 296:100588. PMID: 33774052
Excess circulating human growth hormone (hGH) in vivo is linked to metabolic and growth disorders such as cancer, diabetes, and acromegaly. Consequently, there is considerable interest in developing antagonists of...
9.
Qian Y, Basu R, Mathes S, Arnett N, Duran-Ortiz S, Funk K, et al.
Cancers (Basel) . 2020 Dec; 12(12). PMID: 33291663
Growth hormone (GH) and the GH receptor (GHR) are expressed in a wide range of malignant tumors including melanoma. However, the effect of GH/insulin-like growth factor (IGF) on melanoma in...
10.
List E, Berryman D, Basu R, Buchman M, Funk K, Kulkarni P, et al.
Endocrinology . 2020 Jun; 161(8). PMID: 32556100
A rare 20K isoform of GH-V (here abbreviated as GHv) was discovered in 1998. To date, only 1 research article has characterized this isoform in vivo, observing that GHv treatment...