Prasanna M Chandramouleeswaran
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Explore the profile of Prasanna M Chandramouleeswaran including associated specialties, affiliations and a list of published articles.
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11
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378
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Recent Articles
1.
Roh T, Alex A, Chandramouleeswaran P, Sorrells J, Ho A, Iyer R, et al.
Redox Biol
. 2024 Jul;
75:103280.
PMID: 39083897
The DNA damage response (DDR) is a fundamental readout for evaluating efficacy of cancer therapeutics, many of which target DNA associated processes. Current techniques to evaluate DDR rely on immunostaining...
2.
Chandramouleeswaran P, Guha M, Shimonosono M, Whelan K, Maekawa H, Sachdeva U, et al.
PLoS One
. 2020 Sep;
15(9):e0239625.
PMID: 32966340
During alcohol consumption, the esophageal mucosa is directly exposed to high concentrations of ethanol (EtOH). We therefore investigated the response of normal human esophageal epithelial cell lines EPC1, EPC2 and...
3.
Guha M, Srinivasan S, Sheehan M, Kijima T, Ruthel G, Whelan K, et al.
Oncotarget
. 2019 Nov;
10(58):6245-6259.
PMID: 31692873
Esophageal squamous cell carcinoma (ESCC) is an aggressive cancer with late-stage detection and poor prognosis. This emphasizes the need to identify new markers for early diagnosis and treatment. Altered mitochondrial...
4.
Kasagi Y, Dods K, Wang J, Chandramouleeswaran P, Benitez A, Gambanga F, et al.
J Allergy Clin Immunol
. 2018 Dec;
144(1):171-182.
PMID: 30578874
Background: Fibrosis and stricture are major comorbidities in patients with eosinophilic esophagitis (EoE). Lysyl oxidase (LOX), a collagen cross-linking enzyme, has not been investigated in the context of EoE. Objective:...
5.
Kijima T, Nakagawa H, Shimonosono M, Chandramouleeswaran P, Hara T, Sahu V, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Dec;
7(1):73-91.
PMID: 30510992
Background & Aims: Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized...
6.
Kasagi Y, Chandramouleeswaran P, Whelan K, Tanaka K, Giroux V, Sharma M, et al.
Cell Mol Gastroenterol Hepatol
. 2018 Mar;
5(3):333-352.
PMID: 29552622
Background & Aims: Aberrations in the esophageal proliferation-differentiation gradient are histologic hallmarks in eosinophilic esophagitis (EoE) and gastroesophageal reflux disease. A reliable protocol to grow 3-dimensional (3D) esophageal organoids is...
7.
Fahey L, Chandramouleeswaran P, Guan S, Benitez A, Furuta G, Aceves S, et al.
Clin Transl Gastroenterol
. 2018 Mar;
9(3):139.
PMID: 29511165
Objectives: TSLP has been shown to be associated with eosinophilic esophagitis (EoE). Specifically, children with EoE often have the nucleotides AA or AG instead of GG at the single nucleotide...
8.
Natsuizaka M, Whelan K, Kagawa S, Tanaka K, Giroux V, Chandramouleeswaran P, et al.
Nat Commun
. 2017 Nov;
8(1):1758.
PMID: 29170450
Notch1 transactivates Notch3 to drive terminal differentiation in stratified squamous epithelia. Notch1 and other Notch receptor paralogs cooperate to act as a tumor suppressor in squamous cell carcinomas (SCCs). However,...
9.
Tanaka K, Whelan K, Chandramouleeswaran P, Kagawa S, Rustgi S, Noguchi C, et al.
Am J Cancer Res
. 2016 May;
6(4):781-96.
PMID: 27186430
A polymorphic mutation in the acetaldehyde dehydrogenase 2 (ALDH2) gene has been epidemiologically linked to the high susceptibility to esophageal carcinogenesis for individuals with alcohol use disorders. Mice subjected to...
10.
Chandramouleeswaran P, Shen D, Lee A, Benitez A, Dods K, Gambanga F, et al.
PLoS One
. 2016 Mar;
11(3):e0150968.
PMID: 26992000
Eosinophilic esophagitis (EoE) is a chronic Th2 and food antigen-mediated disease characterized by esophageal eosinophilic infiltration. Thymic stromal lymphopoetin (TSLP), an epithelial derived cytokine which bridges innate and Th2-type adaptive...