Prajna Shanbhogue
Overview
Explore the profile of Prajna Shanbhogue including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
109
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0
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Recent Articles
1.
Shanbhogue P, Hoffmann R, Airola M, Maini R, Hamelin D, Garcia-Diaz M, et al.
J Biol Chem
. 2019 Mar;
294(18):7488-7502.
PMID: 30890560
Neutral sphingomyelinase 2 (nSMase2) produces the bioactive lipid ceramide and has important roles in neurodegeneration, cancer, and exosome formation. Although nSMase2 has low basal activity, it is fully activated by...
2.
Shanbhogue P, Hannun Y
Handb Exp Pharmacol
. 2018 Nov;
259:19-47.
PMID: 30478737
Sphingosine, ceramide, sphingosine-1-phosphate, and other related sphingolipids have emerged as important bioactive molecules involved in a variety of key cellular processes such as cell growth, differentiation, apoptosis, exosome release, and...
3.
Airola M, Shanbhogue P, Shamseddine A, Guja K, Senkal C, Maini R, et al.
Proc Natl Acad Sci U S A
. 2017 Jun;
114(28):E5549-E5558.
PMID: 28652336
Neutral sphingomyelinase 2 (nSMase2, product of the gene) is a key enzyme for ceramide generation that is involved in regulating cellular stress responses and exosome-mediated intercellular communication. nSMase2 is activated...
4.
Fuson K, Rice A, Mahling R, Snow A, Nayak K, Shanbhogue P, et al.
Structure
. 2013 Nov;
22(1):104-15.
PMID: 24239457
Dysferlin plays a critical role in the Ca²⁺-dependent repair of microlesions that occur in the muscle sarcolemma. Of the seven C2 domains in dysferlin, only C2A is reported to bind...