Poornima Bhat-Nakshatri
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Explore the profile of Poornima Bhat-Nakshatri including associated specialties, affiliations and a list of published articles.
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1880
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Recent Articles
1.
Bhat-Nakshatri P, Gao H, Khatpe A, Adebayo A, McGuire P, Erdogan C, et al.
Nat Med
. 2024 Aug;
30(12):3482-3494.
PMID: 39122969
Single-nucleus analysis allows robust cell-type classification and helps to establish relationships between chromatin accessibility and cell-type-specific gene expression. Here, using samples from 92 women of several genetic ancestries, we developed...
2.
Adebayo A, Bhat-Nakshatri P, Davis C, Angus S, Erdogan C, Gao H, et al.
iScience
. 2024 Jun;
27(6):110068.
PMID: 38872973
Most cells in solid tumors are exposed to oxygen levels between 0.5% and 5%. We developed an approach that allows collection, processing, and evaluation of cancer and non-cancer cells under...
3.
Bhat-Nakshatri P, Khatpe A, Chen D, Batic K, Mang H, Herodotou C, et al.
Cancer Res Commun
. 2023 Dec;
4(1):38-54.
PMID: 38059556
Significance: This study provides a single-cell atlas of breast tissues of BRCA1/2 mutation carriers and demonstrates that aberrant signaling due to BRCA1/2 mutations is sufficient to initiate breast cancer by...
4.
Kumar B, Khatpe A, Guanglong J, Batic K, Bhat-Nakshatri P, Granatir M, et al.
Nat Commun
. 2023 Sep;
14(1):5683.
PMID: 37709737
The biologic basis of genetic ancestry-dependent variability in disease incidence and outcome is just beginning to be explored. We recently reported enrichment of a population of ZEB1-expressing cells located adjacent...
5.
Wang R, Kumar B, Bhat-Nakshatri P, Khatpe A, Murphy M, Wanczyk K, et al.
iScience
. 2023 Apr;
26(4):106541.
PMID: 37102148
Skeletal muscle dysfunction or reprogramming due to the effects of the cancer secretome is observed in multiple malignancies. Although mouse models are routinely used to study skeletal muscle defects in...
6.
Khatpe A, Dirks R, Bhat-Nakshatri P, Mang H, Batic K, Swiezy S, et al.
Cancer Res
. 2023 Apr;
83(8):1345-1360.
PMID: 37057595
Significance: The chr.8q24.3 amplicon-resident gene TONSL is upregulated during the initial steps of tumorigenesis to support neoplastic transformation by increasing DNA repair and represents a potential therapeutic target for treating...
7.
Kumar B, Adebayo A, Prasad M, Capitano M, Wang R, Bhat-Nakshatri P, et al.
Sci Adv
. 2022 Jan;
8(2):eabh3375.
PMID: 35020422
Preclinical studies of primary cancer cells are typically done after tumors are removed from patients or animals at ambient atmospheric oxygen (O, ~21%). However, O concentrations in organs are in...
8.
Bhat-Nakshatri P, Marino N, Gao H, Liu Y, Storniolo A, Nakshatri H
STAR Protoc
. 2022 Jan;
3(1):101047.
PMID: 34977686
The Komen Tissue Bank is the only biorepository in the world for normal breast tissues from women. Below we report the acquisition and processing of breast tissue from volunteer donors...
9.
Kumar B, Bhat-Nakshatri P, Maguire C, Jacobsen M, Temm C, Sandusky G, et al.
Mol Cancer Res
. 2021 Jul;
19(11):1802-1817.
PMID: 34285086
Breast cancers are classified into five intrinsic subtypes and 10 integrative clusters based on gene expression patterns and genomic aberrations, respectively. Although the cell-of-origin, adaptive plasticity, and genomic aberrations shape...
10.
Wang R, Bhat-Nakshatri P, Zhong X, Zimmers T, Nakshatri H
Endocrinology
. 2021 Jul;
162(10).
PMID: 34265069
Cancer-induced skeletal muscle defects show sex-specific differences in severity with men performing poorly compared to women. Hormones and sex chromosomal differences are suggested to mediate these differences, but the functional...