Polynikis Kaimakis
Overview
Explore the profile of Polynikis Kaimakis including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
878
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Recent Articles
1.
Mouse Nr2f1 haploinsufficiency unveils new pathological mechanisms of a human optic atrophy syndrome
Bertacchi M, Gruart A, Kaimakis P, Allet C, Serra L, Giacobini P, et al.
EMBO Mol Med
. 2019 Jul;
11(8):e10291.
PMID: 31318166
Optic nerve atrophy represents the most common form of hereditary optic neuropathies leading to vision impairment. The recently described Bosch-Boonstra-Schaaf optic atrophy (BBSOA) syndrome denotes an autosomal dominant genetic form...
2.
Mercurio S, Serra L, Motta A, Gesuita L, Sanchez-Arrones L, Inverardi F, et al.
iScience
. 2019 May;
15:257-273.
PMID: 31082736
Visual system development involves the formation of neuronal projections connecting the retina to the thalamic dorso-lateral geniculate nucleus (dLGN) and the thalamus to the visual cerebral cortex. Patients carrying mutations...
3.
Kauts M, De Leo B, Rodriguez-Seoane C, Ronn R, Glykofrydis F, Maglitto A, et al.
Stem Cell Reports
. 2018 Sep;
11(4):1009-1020.
PMID: 30197119
Mast cells are tissue-resident immune cells. Their overgrowth/overactivation results in a range of common distressing, sometimes life-threatening disorders, including asthma, psoriasis, anaphylaxis, and mastocytosis. Currently, drug discovery is hampered by...
4.
Esteve P, Crespo I, Kaimakis P, Sandonis A, Bovolenta P
Cereb Cortex
. 2018 Aug;
29(3):1059-1074.
PMID: 30084950
The mammalian dorsal telencephalic neuroepithelium develops-from medial to lateral-into the choroid plaque, cortical hem, hippocampal primordium and isocortex under the influence of Bmp, Wnt and Notch signaling. Correct telencephalic development...
5.
Kauts M, Rodriguez-Seoane C, Kaimakis P, Mendes S, Cortes-Lavaud X, Hill U, et al.
Stem Cell Reports
. 2017 Dec;
10(1):151-165.
PMID: 29276152
In vivo hematopoietic generation occurs in waves of primitive and definitive cell emergence. Differentiation cultures of pluripotent embryonic stem cells (ESCs) offer an accessible source of hematopoietic cells for blood-related...
6.
Eich C, Arlt J, Vink C, Solaimani Kartalaei P, Kaimakis P, Mariani S, et al.
J Exp Med
. 2017 Dec;
215(1):233-248.
PMID: 29217535
Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play central roles in hematopoietic fate establishment. Although Gata2 is...
7.
Kaimakis P, de Pater E, Eich C, Solaimani Kartalaei P, Kauts M, Vink C, et al.
Blood
. 2016 Feb;
127(11):1426-37.
PMID: 26834239
The Gata2 transcription factor is a pivotal regulator of hematopoietic cell development and maintenance, highlighted by the fact that Gata2 haploinsufficiency has been identified as the cause of some familial...
8.
de Pater E, Kaimakis P, Vink C, Yokomizo T, Yamada-Inagawa T, van der Linden R, et al.
J Exp Med
. 2013 Dec;
210(13):2843-50.
PMID: 24297996
Knowledge of the key transcription factors that drive hematopoietic stem cell (HSC) generation is of particular importance for current hematopoietic regenerative approaches and reprogramming strategies. Whereas GATA2 has long been...
9.
Imanirad P, Solaimani Kartalaei P, Crisan M, Vink C, Yamada-Inagawa T, de Pater E, et al.
Stem Cell Res
. 2013 Oct;
12(1):24-35.
PMID: 24141110
Hypoxia affects many physiologic processes during early stages of mammalian ontogeny, particularly placental and vascular development. In the adult, the hypoxic bone marrow microenvironment plays a role in regulating hematopoietic...
10.
Wilson N, Foster S, Wang X, Knezevic K, Schutte J, Kaimakis P, et al.
Cell Stem Cell
. 2010 Oct;
7(4):532-44.
PMID: 20887958
Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide binding patterns and combinatorial interactions for ten key...