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Piyu Zhao

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Articles 37
Citations 568
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Recent Articles
1.
Paranawithana N, Chiaffarelli R, Kretschmer J, Buchanan E, Lopez K, Zhao P, et al.
Inorg Chem . 2024 Feb; 63(9):4072-4077. PMID: 38385753
This study was designed to test whether the single appended phosphonate group in GdDOTA-1AmP is sufficient for catalyzing the exchange of proton from the single inner-sphere water-exchanging molecule. Unlike the...
2.
Paranawithana N, Martins A, Clavijo Jordan V, Zhao P, Chirayil S, Meloni G, et al.
J Am Chem Soc . 2019 Jul; 141(28):11009-11018. PMID: 31268706
The design, synthesis, and properties of a new gadolinium-based copper-responsive magnetic resonance imaging (MRI) contrast agent is presented. The sensor (GdL) has high selectivity for copper ions and exhibits a...
3.
Martins A, Clavijo Jordan V, Bochner F, Chirayil S, Paranawithana N, Zhang S, et al.
J Am Chem Soc . 2018 Nov; 140(50):17456-17464. PMID: 30484648
It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based Zn-sensitive agent. This study...
4.
Zhang L, Martins A, Zhao P, Tieu M, Esteban-Gomez D, McCandless G, et al.
J Am Chem Soc . 2017 Oct; 139(48):17431-17437. PMID: 29083166
A previous report demonstrated that EuDO3A could be used as an NMR shift reagent for imaging extracellular lactate produced by cancer cells using CEST imaging. In this work, a series...
5.
Zhang L, Evbuomwan O, Tieu M, Zhao P, Martins A, Sherry A
Philos Trans A Math Phys Eng Sci . 2017 Oct; 375(2107). PMID: 29038382
The CEST properties of EuDOTA-tetraamide complexes bearing pendant carboxylate and carboxyl ethyl esters were measured as a function of pH. The CEST signal from the Eu-bound water molecule decreased in...
6.
Zhang L, Martins A, Zhao P, Wu Y, Tircso G, Sherry A
Angew Chem Int Ed Engl . 2017 Oct; 56(52):16626-16630. PMID: 29024242
The CEST and T /T relaxation properties of a series of Eu and Dy DOTA-tetraamide complexes with four appended primary amine groups are measured as a function of pH. The...
7.
Zhang L, Martins A, Mai Y, Zhao P, Funk A, Jordan M, et al.
Chemistry . 2016 Dec; 23(8):1752-1756. PMID: 27987233
Overproduction of lactate is a hallmark of cancer, yet a method to quantitatively measure lactate production by cancer cells is not straight-forward. Chemical exchange saturation transfer magnetic resonance imaging (CEST...
8.
Xing Y, Jindal A, Regueiro-Figueroa M, Le Fur M, Kervarec N, Zhao P, et al.
Chemistry . 2016 Oct; 22(46):16657-16667. PMID: 27723138
Recently developed dynamic nuclear polarization (DNP) technology offers the potential of increasing the NMR sensitivity of even rare nuclei for biological imaging applications. Hyperpolarized Y is an ideal candidate because...
9.
Kumas C, Fernando W, Zhao P, Regueiro-Figueroa M, Kiefer G, Martins A, et al.
Inorg Chem . 2016 Sep; 55(18):9297-305. PMID: 27603690
Lanthanide complexes with DOTA-tetraglycinate (DOTA-(gly)4) heavily favor the square antiprismatic (SAP) coordination isomer in aqueous solution, a structural feature that has made them useful as water-based paraCEST agents. In an...
10.
Fernando W, Martins A, Zhao P, Wu Y, Kiefer G, Platas-Iglesias C, et al.
Inorg Chem . 2016 Mar; 55(6):3007-14. PMID: 26937683
EuDOTA-tetraamide complexes as paraCEST agents offer an attractive platform for designing biological sensors and responsive agents. The early versions of these agents showed low sensitivity at temperature and power levels...