Pirkko Mattila
Overview
Explore the profile of Pirkko Mattila including associated specialties, affiliations and a list of published articles.
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43
Citations
1164
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Recent Articles
1.
Liukkonen M, Helotera H, Siintamo L, Ghimire B, Mattila P, Kivinen N, et al.
Invest Ophthalmol Vis Sci
. 2024 Nov;
65(13):30.
PMID: 39546296
Purpose: Localized diseases can be affected by and affect the systemic environment via blood circulation. In this study, we explored the differences in circulating serum mRNAs between patients with wet...
2.
Cabrera L, Jokiranta S, Maki S, Miettinen S, Kant R, Kareinen L, et al.
PLoS Pathog
. 2024 Aug;
20(8):e1012368.
PMID: 39172744
The severity of COVID-19 is linked to excessive inflammation. Neutrophils represent a critical arm of the innate immune response and are major mediators of inflammation, but their role in COVID-19...
3.
Yu Y, Hou W, Liu Y, Wang H, Dong L, Mai Y, et al.
Nat Biotechnol
. 2023 Oct;
42(7):1150.
PMID: 37783850
No abstract available.
4.
Yu Y, Hou W, Liu Y, Wang H, Dong L, Mai Y, et al.
Nat Biotechnol
. 2023 Sep;
42(7):1118-1132.
PMID: 37679545
Certified RNA reference materials are indispensable for assessing the reliability of RNA sequencing to detect intrinsically small biological differences in clinical settings, such as molecular subtyping of diseases. As part...
5.
Salmikangas M, Laaksonen M, Edgren H, Salgado M, Suoranta A, Mattila P, et al.
PLoS One
. 2023 May;
18(5):e0285524.
PMID: 37146093
Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine carcinoma that is frequently divided into Merkel cell polyomavirus negative and positive tumors due their distinct genomic and transcriptomic profiles, and...
6.
Kerkela E, Lahtela J, Larjo A, Impola U, Maenpaa L, Mattila P
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36361688
Being enucleated, RBCs lack typical transcriptomes, but are known to contain small amounts of diverse long transcripts and microRNAs. However, the exact role and importance of these RNAs are lacking....
7.
Kangas S, Teppo J, Lahtinen M, Suoranta A, Ghimire B, Mattila P, et al.
Transl Neurodegener
. 2022 Apr;
11(1):22.
PMID: 35418104
Background: Transcriptomic and proteomic profiling of human brain tissue is hindered by the availability of fresh samples from living patients. Postmortem samples usually represent the advanced disease stage of the...
8.
Rahikkala E, Urpa L, Ghimire B, Topa H, Kurki M, Koskela M, et al.
Eur J Hum Genet
. 2022 Jan;
30(5):619-627.
PMID: 35087184
Biallelic loss-of-function variants in the SMG9 gene, encoding a regulatory subunit of the mRNA nonsense-mediated decay (NMD) machinery, are reported to cause heart and brain malformation syndrome. Here we report...
9.
Ianevski A, Lahtela J, Javarappa K, Sergeev P, Ghimire B, Gautam P, et al.
Sci Adv
. 2021 Feb;
7(8).
PMID: 33608276
The extensive drug resistance requires rational approaches to design personalized combinatorial treatments that exploit patient-specific therapeutic vulnerabilities to selectively target disease-driving cell subpopulations. To solve the combinatorial explosion challenge, we...
10.
Laulajainen-Hongisto A, Lyly A, Hanif T, Dhaygude K, Kankainen M, Renkonen R, et al.
Clin Transl Allergy
. 2020 Nov;
10(1):45.
PMID: 33133517
Genome wide association studies (GWASs) have revealed several airway disease-associated risk loci. Their role in the onset of asthma, allergic rhinitis (AR) or chronic rhinosinusitis (CRS), however, is not yet...