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Piotr Sunderland

Explore the profile of Piotr Sunderland including associated specialties, affiliations and a list of published articles. Areas
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Articles 9
Citations 258
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Recent Articles
1.
Gluchowska A, Cysewski D, Baj-Krzyworzeka M, Szatanek R, Weglarczyk K, Podszywalow-Bartnicka P, et al.
Geroscience . 2022 Jul; 44(6):2863-2884. PMID: 35900662
Atherosclerosis, a common age-related disease, is characterized by intense immunological activity. Atherosclerotic plaque is composed of endothelial cells, vascular smooth muscle cells (VSMCs), lipids and immune cells infiltrating from the...
2.
Sikora E, Czarnecka-Herok J, Bojko A, Sunderland P
Semin Cancer Biol . 2020 Dec; 81:83-95. PMID: 33271316
Polyploid somatic cells have 'programmed' roles in normal development and stress responses. Transient polyploidy states have been observed in several tumor types at early stages of tumorigenesis. They can give...
3.
Bojko A, Staniak K, Czarnecka-Herok J, Sunderland P, Dudkowska M, Sliwinska M, et al.
Int J Mol Sci . 2020 Aug; 21(17). PMID: 32846959
The induction of senescence/polyploidization and their role in cancer recurrence is still a poorly explored issue. We showed that MDA-MB-231 and MCF-7 breast cancer cells underwent reversible senescence/polyploidization upon pulse...
4.
Sunderland P, Augustyniak J, Lenart J, Buzanska L, Carlessi L, Delia D, et al.
Mech Ageing Dev . 2020 Jul; 190:111296. PMID: 32621937
ATM is a kinase involved in DNA damage response (DDR), regulation of response to oxidative stress, autophagy and mitophagy. Mutations in the ATM gene in humans result in ataxi A-Telangiectasia...
5.
Piechota M, Sunderland P, Wysocka A, Nalberczak M, Sliwinska M, Radwanska K, et al.
Oncotarget . 2016 Oct; 7(49):81099-81109. PMID: 27768595
One of the features of cellular senescence is the activity of senescence-associated- β-galactosidase (SA-β-gal). The main purpose of this study was to evaluate this marker of senescence in aging neurons....
6.
Przybylska D, Janiszewska D, Gozdzik A, Bielak-Zmijewska A, Sunderland P, Sikora E, et al.
Oncotarget . 2016 Sep; 7(41):66429-66443. PMID: 27655718
Senescence is a stress response characterized by an irreversible growth arrest and alterations in certain cell functions. It is believed that both double-strand DNA breaks (DSB) and increased ROS level...
7.
Mosieniak G, Sliwinska M, Przybylska D, Grabowska W, Sunderland P, Bielak-Zmijewska A, et al.
Int J Biochem Cell Biol . 2016 Feb; 74:33-43. PMID: 26916504
Cellular senescence is recognized as a potent anticancer mechanism that inhibits carcinogenesis. Cancer cells can also undergo senescence upon chemo- or radiotherapy. Curcumin, a natural polyphenol derived from the rhizome...
8.
Mosieniak G, Sliwinska M, Alster O, Strzeszewska A, Sunderland P, Piechota M, et al.
Neoplasia . 2015 Dec; 17(12):882-893. PMID: 26696370
Cancer cells can undergo stress-induced premature senescence, which is considered to be a desirable outcome of anticancer treatment. However, the escape from senescence and cancer cell repopulation give rise to...
9.
Piechota M, Sunderland P
Postepy Biochem . 2014 Aug; 60(2):177-86. PMID: 25134353
Ageing leads to irreversible alterations in the nervous system, which to various extent impair its functions such as capacity to learn and memory. In old neurons and brain, similarly to...