Pijush K Das
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Explore the profile of Pijush K Das including associated specialties, affiliations and a list of published articles.
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43
Citations
795
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Recent Articles
1.
Biswas A, Bhattacharjee A, Das P
Methods Mol Biol
. 2024 Apr;
2782:137-146.
PMID: 38622398
Leishmania, an intra-macrophage kinetoplastid parasite, modulates a vast array of defensive mechanisms of the host macrophages to create a comfortable environment for their survival. When the host encounters intracellular pathogens,...
2.
Roy S, Gupta A, Banerjee M, Das P, Ukil A
Cell Immunol
. 2023 Aug;
391-392:104758.
PMID: 37651886
The anti-inflammatory role of the programmed death-1 receptor (PD-1) is well appreciated. However, the mechanism of how PD-1 signaling inhibits the pro-inflammatory cytokine responses in macrophages, which is further exploited...
3.
Gupta A, Roy S, Das P
J Antimicrob Chemother
. 2020 Sep;
76(1):135-145.
PMID: 32995849
Objectives: To evaluate the antileishmanial efficacy of genipin, which specifically inhibits uncoupling protein 2 (UCP2) that is induced in leishmaniasis to neutralize reactive oxygen species (ROS). Methods: The effect of...
4.
Saha A, Bhattacharjee A, Vij A, Das P, Bhattacharya A, Biswas A
Front Pharmacol
. 2020 Jul;
11:782.
PMID: 32670055
With the identification of novel cAMP binding effector molecules in , the role of cAMP in kinetoplastida parasites gained an intriguing breakthrough. Despite earlier demonstrations of the role of cAMP...
5.
Roy S, Saha S, Gupta P, Ukil A, Das P
J Cell Sci
. 2019 Mar;
132(9).
PMID: 30910830
Previously, we documented the role of the programmed death-1 (PD-1, also known as PDCD1) pathway in macrophage apoptosis and the downregulation of this signaling during infection by the intra-macrophage parasite...
6.
Gupta A, Ghosh K, Palit S, Barua J, Das P, Ukil A
FASEB J
. 2017 Aug;
31(11):5087-5101.
PMID: 28765172
In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher level of IL-1β over the infected control. Moreover, administering anti-IL-1β antibody to infected Amp B-treated mice...
7.
Roy S, Gupta P, Palit S, Basu M, Ukil A, Das P
Clin Transl Immunology
. 2017 Jul;
6(5):e137.
PMID: 28690843
Programmed death-1 receptor (PD-1) expressed in many immune cells is known to trigger T-cell exhaustion but the significance of macrophage-associated PD-1 in relevance to macrophage apoptosis is not known. This...
8.
Biswas A, Bhattacharya A, Vij A, Das P
Int J Biochem Cell Biol
. 2017 Mar;
86:1-13.
PMID: 28268199
Exposure of Leishmania donovani to macrophage phagolysosome conditions (PC) (37°C and pH 5.5) led to increased intracellular cAMP and cAMP-mediated responses, which help in intra-macrophage survival pre-requisite for infectivity. In...
9.
Gupta P, Srivastav S, Saha S, Das P, Ukil A
Cell Death Differ
. 2016 Sep;
23(11):1815-1826.
PMID: 27662364
In order to establish infection, intra-macrophage parasite Leishmania donovani needs to inhibit host defense parameters like inflammatory cytokine production and apoptosis. In the present study, we demonstrate that the parasite...
10.
Srivastav S, Saha A, Barua J, Ukil A, Das P
Eur J Immunol
. 2015 Jul;
45(10):2787-97.
PMID: 26140693
Intramacrophage protozoan parasite Leishmania donovani, causative agent of visceral leishmaniasis, escapes Toll-like receptor (TLR) dependent early host immune response by inducing the deubiquitinating enzyme A20, which is sustained up to...