Pieter Van Wielendaele
Overview
Explore the profile of Pieter Van Wielendaele including associated specialties, affiliations and a list of published articles.
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28
Citations
609
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Recent Articles
1.
Opuni K, Russ M, Geens R, Vocht L, Wielendaele P, Debuy C, et al.
Comput Struct Biotechnol J
. 2024 Sep;
23:3300-3314.
PMID: 39296809
Background: Bioanalytical methods that enable rapid and high-detail characterization of binding specificities and strengths of protein complexes with low sample consumption are highly desired. The interaction between a camelid single...
2.
Espadinha M, De Loose J, Corthaut S, Thys S, Van Rymenant Y, Verhulst E, et al.
Eur J Med Chem
. 2024 Apr;
270:116389.
PMID: 38593588
Dipeptidyl peptidases (DPP) 8 and 9 are intracellular serine proteases that play key roles in various biological processes and recent findings highlight DPP8 and DPP9 as potential therapeutic targets for...
3.
Patsi H, Kilpelainen T, Jumppanen M, Uhari-Vaananen J, Wielendaele P, De Lorenzo F, et al.
J Med Chem
. 2024 Mar;
67(7):5421-5436.
PMID: 38546708
A series of novel 5-aminothiazole-based ligands for prolyl oligopeptidase (PREP) comprise selective, potent modulators of the protein-protein interaction (PPI)-mediated functions of PREP, although they are only weak inhibitors of the...
4.
Claesen K, De Loose J, Wielendaele P, De Bruyn E, Sim Y, Thys S, et al.
Int J Mol Sci
. 2023 Feb;
24(4).
PMID: 36835137
Carboxypeptidase U (CPU, TAFIa, CPB2) is a potent attenuator of fibrinolysis that is mainly synthesized by the liver as its inactive precursor proCPU. Aside from its antifibrinolytic properties, evidence exists...
5.
De Zutter A, Crijns H, Berghmans N, Garcia-Caballero M, Vanbrabant L, Portner N, et al.
Cancers (Basel)
. 2021 Oct;
13(20).
PMID: 34680238
Growth factors such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and epidermal growth factor (EGF) are important angiogenesis-mediating factors. They exert their effects not only through their...
6.
Magez S, Li Z, Nguyen H, Pinto Torres J, Wielendaele P, Radwanska M, et al.
Pathogens
. 2021 Aug;
10(8).
PMID: 34451514
Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic parasites. The only sustainable method for global control of these infection is through vaccination of livestock animals. Despite multiple reports...
7.
Emini Veseli B, Wielendaele P, Delibegovic M, Martinet W, De Meyer G
Int J Mol Sci
. 2021 Jun;
22(11).
PMID: 34073144
Angiogenesis is the process of new blood vessel formation. In this complex orchestrated growth, many factors are included. Lately, focus has shifted to endothelial cell metabolism, particularly to the PFKFB3...
8.
Bottari F, Daems E, de Vries A, Wielendaele P, Trashin S, Blust R, et al.
J Am Chem Soc
. 2020 Nov;
142(46):19622-19630.
PMID: 33166132
In this manuscript, we compare different analytical methodologies to validate or disprove the binding capabilities of aptamer sequences. This was prompted by the lack of a universally accepted and robust...
9.
Emini Veseli B, Perrotta P, Wielendaele P, Lambeir A, Abdali A, Bellosta S, et al.
FEBS Lett
. 2020 Jul;
594(18):3067-3075.
PMID: 32620030
6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolytic pathway, and it plays an essential role in angiogenesis. 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) is frequently used as a glycolysis inhibitor and...
10.
Wulff J, Sierra I, Sterkel M, Holtof M, Wielendaele P, Francini F, et al.
Insect Biochem Mol Biol
. 2017 Jan;
81:91-102.
PMID: 28089691
To grow and develop insects must undergo ecdysis. During this process, the individual sheds the old cuticle to emerge as the following developmental stage. During ecdysis, different programed behaviors are...