Pierre Genevaux
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Explore the profile of Pierre Genevaux including associated specialties, affiliations and a list of published articles.
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61
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1805
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Recent Articles
1.
Xu X, Barriot R, Voisin B, Arrowsmith T, Usher B, Gutierrez C, et al.
Nat Commun
. 2024 Nov;
15(1):9596.
PMID: 39505885
Toxins of toxin-antitoxin systems use diverse mechanisms to inhibit bacterial growth. In this study, we characterize the translation inhibitor toxin MenT3 of Mycobacterium tuberculosis, the bacterium responsible for tuberculosis in...
2.
Arrowsmith T, Xu X, Xu S, Usher B, Stokes P, Guest M, et al.
Nat Commun
. 2024 Sep;
15(1):7719.
PMID: 39231966
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance. The Mycobacterium tuberculosis NTase toxin family, MenT, modifies tRNAs to block translation. MenT toxin...
3.
Marszalek J, De Los Rios P, Cyr D, Mayer M, Adupa V, Andreasson C, et al.
Cell Stress Chaperones
. 2024 Feb;
29(1):21-33.
PMID: 38320449
J-domain proteins (JDPs) are the largest family of chaperones in most organisms, but much of how they function within the network of other chaperones and protein quality control machineries is...
4.
Xu X, Usher B, Gutierrez C, Barriot R, Arrowsmith T, Han X, et al.
Nat Commun
. 2023 Aug;
14(1):4644.
PMID: 37591829
Mycobacterium tuberculosis, the bacterium responsible for human tuberculosis, has a genome encoding a remarkably high number of toxin-antitoxin systems of largely unknown function. We have recently shown that the M....
5.
Mansour M, Giudice E, Xu X, Akarsu H, Bordes P, Guillet V, et al.
Nat Commun
. 2022 May;
13(1):2641.
PMID: 35552387
Toxins of toxin-antitoxin systems use diverse mechanisms to control bacterial growth. Here, we focus on the deleterious toxin of the atypical tripartite toxin-antitoxin-chaperone (TAC) system of Mycobacterium tuberculosis, whose inhibition...
6.
Zuily L, Lahrach N, Fassler R, Genest O, Faller P, Seneque O, et al.
mBio
. 2022 Mar;
13(2):e0325121.
PMID: 35289645
Copper is well known for its antimicrobial and antiviral properties. Under aerobic conditions, copper toxicity relies in part on the production of reactive oxygen species (ROS), especially in the periplasmic...
7.
Zhao L, Castanie-Cornet M, Kumar S, Genevaux P, Hayer-Hartl M, Hartl F
Mol Cell
. 2021 Jun;
81(14):2914-2928.e7.
PMID: 34107307
Molecular chaperones assist with protein folding by interacting with nascent polypeptide chains (NCs) during translation. Whether the ribosome can sense chaperone defects and, in response, abort translation of misfolding NCs...
8.
Bordes P, Genevaux P
Front Mol Biosci
. 2021 Jun;
8:691399.
PMID: 34079824
Toxin-antitoxin (TA) systems are small genetic elements composed of a noxious toxin and a counteracting cognate antitoxin. Although they are widespread in bacterial chromosomes and in mobile genetic elements, their...
9.
Fauvet B, Finka A, Castanie-Cornet M, Cirinesi A, Genevaux P, Quadroni M, et al.
Front Mol Biosci
. 2021 May;
8:653073.
PMID: 33937334
In eukaryotes, the 90-kDa heat shock proteins (Hsp90s) are profusely studied chaperones that, together with 70-kDa heat shock proteins (Hsp70s), control protein homeostasis. In bacteria, however, the function of Hsp90...
10.
Texier P, Bordes P, Nagpal J, Sala A, Mansour M, Cirinesi A, et al.
J Mol Biol
. 2021 Jan;
433(5):166815.
PMID: 33450247
Bacterial toxin-antitoxin (TA) systems are composed of a deleterious toxin and its antagonistic antitoxin. They are widespread in bacterial genomes and mobile genetic elements, and their functions remain largely unknown....