Phyllis C Pugh
Overview
Explore the profile of Phyllis C Pugh including associated specialties, affiliations and a list of published articles.
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12
Citations
218
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Recent Articles
1.
Rana S, Pugh P, Wyss J, Clinton S, Kerman I
Physiol Behav
. 2018 Dec;
199:375-385.
PMID: 30529343
We previously demonstrated independent effects of early-life experience (ELE) and trait aggression (TA) on resting heart rate (HR) and mean arterial pressure (MAP) in rats. The present study examined the...
2.
Laszczyk A, Fox-Quick S, Vo H, Nettles D, Pugh P, Overstreet-Wadiche L, et al.
Neurobiol Aging
. 2017 Aug;
59:41-54.
PMID: 28837861
Although the absence of the age-regulating klotho protein causes klotho-deficient mice to rapidly develop cognitive impairment and increasing klotho enhances hippocampal-dependent memory, the cellular effects of klotho that mediate hippocampal-dependent...
3.
Rana S, Pugh P, Katz E, Stringfellow S, Lin C, Wyss J, et al.
Am J Physiol Regul Integr Comp Physiol
. 2016 Jun;
311(2):R272-86.
PMID: 27280432
Early-life experience (ELE) can significantly affect life-long health and disease, including cardiovascular function. Specific dimensions of emotionality also modify risk of disease, and aggressive traits along with social inhibition have...
4.
McCoy C, Golf S, Melendez-Ferro M, Perez-Costas E, Glover M, Jackson N, et al.
Neuroscience
. 2016 Mar;
324:469-484.
PMID: 26979051
Individual differences in human temperament can increase the risk of psychiatric disorders like depression and anxiety. Our laboratory utilized a rat model of temperamental differences to assess neurodevelopmental factors underlying...
5.
Cohen J, Glover M, Pugh P, Fant A, Simmons R, Akil H, et al.
Dev Neurosci
. 2015 Mar;
37(3):203-14.
PMID: 25791846
The early-life environment critically influences neurodevelopment and later psychological health. To elucidate neural and environmental elements that shape emotional behavior, we developed a rat model of individual differences in temperament...
6.
Rana S, Pugh P, Jackson N, Clinton S, Kerman I
Neurosci Lett
. 2014 Dec;
584:146-50.
PMID: 25451726
Early-life experience strongly impacts neurodevelopment and stress susceptibility in adulthood. Maternal separation (MS), an established model of early-life adversity, has been shown to negatively impact behavioral and endocrine responses to...
7.
Jayakar S, Pugh P, Dale Z, Starr E, Cole S, Margiotta J
Mol Cell Neurosci
. 2014 Aug;
63:1-12.
PMID: 25168001
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide found at synapses throughout the central and autonomic nervous system. We previously found that PACAP engages a selective G-protein coupled receptor...
8.
Shah N, Pugh P, Nam H, Rosenthal D, van Wijk D, Gaszner B, et al.
J Chem Neuroanat
. 2013 May;
52:25-35.
PMID: 23707488
Numerous motivated behaviors require simultaneous activation of somatomotor and autonomic functions. We have previously characterized the organization of brain circuits that may mediate this integration. Presympathetic premotor neurons (PSPMNs) that...
9.
Chancey J, Adlaf E, Sapp M, Pugh P, Wadiche J, Overstreet-Wadiche L
J Neurosci
. 2013 Apr;
33(15):6614-22.
PMID: 23575858
Neural activity enhances adult neurogenesis, enabling experience to influence the construction of new circuits. GABAA receptor-mediated depolarization of newborn neurons in the adult and developing brain promotes glutamatergic synaptic integration...
10.
Pugh P, Jayakar S, Margiotta J
Mol Cell Neurosci
. 2009 Dec;
43(2):244-57.
PMID: 19958833
Neuropeptides collaborate with conventional neurotransmitters to regulate synaptic output. Pituitary adenylate cyclase-activating polypeptide (PACAP) co-localizes with acetylcholine in presynaptic nerve terminals, is released by stimulation, and enhances nicotinic acetylcholine receptor-...