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Phillip J White

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Articles 41
Citations 1793
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Recent Articles
1.
White P, Wewer Albrechtsen N, Campbell J
Nat Rev Endocrinol . 2025 Mar; PMID: 40055529
The pancreatic islets of Langerhans are central to fine-tuning metabolism to ensure metabolic homeostasis during the transition between fasting and feeding. Insulin and glucagon, the principal hormones generated and secreted...
2.
Karady J, McGarrah R, Nguyen M, Giamberardino S, Meyersohn N, Lu M, et al.
Am J Prev Cardiol . 2024 May; 18:100680. PMID: 38764778
Objectives: To determine the relationship between lipoprotein particle size/number with hepatic steatosis (HS), given its association with traditional lipoproteins and coronary atherosclerosis. Methods: Individuals with available CT data and blood...
3.
Verkerke A, Wang D, Yoshida N, Taxin Z, Shi X, Zheng S, et al.
Cell . 2024 Apr; 187(10):2359-2374.e18. PMID: 38653240
Brown adipose tissue (BAT) is best known for thermogenesis. Rodent studies demonstrated that enhanced BAT thermogenesis is tightly associated with increased energy expenditure, reduced body weight, and improved glucose homeostasis....
4.
Bubrick E, McDannold N, White P
Epilepsy Curr . 2022 Dec; 22(3):156-160. PMID: 36474831
Patients with drug-resistant epilepsy (DRE) who are not surgical candidates have unacceptably few treatment options. Benefits of implanted electrostimulatory devices are still largely palliative, and many patients are not eligible...
5.
Balikcioglu P, Jachthuber Trub C, Balikcioglu M, Ilkayeva O, White P, Muehlbauer M, et al.
Endocrinol Diabetes Metab . 2022 Nov; 6(1):e388. PMID: 36415168
Objectives: Insulin resistance (IR) in adolescents with obesity is associated with a sex-dependent metabolic 'signature' comprising the branched-chain amino acids (BCAAs), glutamate/glutamine, C3/C5 acylcarnitines and uric acid. Here, we compared...
6.
Sargsyan A, Doridot L, Hannou S, Tong W, Srinivasan H, Ivison R, et al.
JCI Insight . 2022 Nov; 8(1). PMID: 36413406
Carbohydrate response element-binding protein (ChREBP) is a carbohydrate-sensing transcription factor that regulates both adaptive and maladaptive genomic responses in coordination of systemic fuel homeostasis. Genetic variants in the ChREBP locus...
7.
McGarrah R, White P
Nat Rev Cardiol . 2022 Sep; 20(2):77-89. PMID: 36064969
Research conducted in the past 15 years has yielded crucial insights that are reshaping our understanding of the systems physiology of branched-chain amino acid (BCAA) metabolism and the molecular mechanisms...
8.
Grenier-Larouche T, Kwee L, Deleye Y, Leon-Mimila P, Walejko J, McGarrah R, et al.
JCI Insight . 2022 Jul; 7(15). PMID: 35797133
Hepatic de novo lipogenesis is influenced by the branched-chain α-keto acid dehydrogenase (BCKDH) kinase (BCKDK). Here, we aimed to determine whether circulating levels of the immediate substrates of BCKDH, the...
9.
Chandra R, Aryal D, Douros J, Shahid R, Davis S, Campbell J, et al.
PLoS One . 2022 Jun; 17(6):e0270329. PMID: 35749484
Objective: Immunoglobulin-like Domain-Containing Receptor 1 (ILDR1) is expressed on nutrient sensing cholecystokinin-positive enteroendocrine cells of the gastrointestinal tract and it has the unique ability to induce fat-mediated CCK secretion. However,...
10.
Patel S, Liu N, Piaker S, Gulko A, Andrade M, Heyward F, et al.
Sci Transl Med . 2022 Mar; 14(637):eabh3831. PMID: 35320000
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3...