Phillip H Beske
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Explore the profile of Phillip H Beske including associated specialties, affiliations and a list of published articles.
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12
Citations
91
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Recent Articles
1.
Beske P, Harvilchuck J, Gibbs S, Green C, Iyer L, OLoughlin K, et al.
Disaster Med Public Health Prep
. 2023 Dec;
17:e550.
PMID: 38044835
Objective: Evidence of myelosuppression has been negatively correlated with patient outcomes following cases of high dose sulfur mustard (SM) exposure. These hematologic complications can negatively impact overall immune function and...
2.
Achzet L, Astruc-Diaz F, Beske P, Natale N, Denton T, Jackson D
Pharmaceutics
. 2021 May;
13(5).
PMID: 33946313
Strokes remain one of the leading causes of disability within the United States. Despite an enormous amount of research effort within the scientific community, very few therapeutics are available for...
3.
Beske P, Wilhelm C, Harvilchuck J, Platoff Jr G, Yeung D
Mil Med
. 2020 Dec;
187(1-2):e106-e115.
PMID: 33346363
Introduction: While exposure to sulfur mustard (SM) is commonly associated with the production of vesicating dermal, ocular, and respiratory injuries, systemic damage to bone marrow and lymphatic tissue can decrease...
4.
McCarren H, Eisen M, Nguyen D, Dubee P, Ardinger C, Dunn E, et al.
Epilepsy Res
. 2020 Mar;
162:106320.
PMID: 32182542
Purpose: To develop and characterize a mouse model of spontaneous recurrent seizures following nerve agent-induced status epilepticus (SE) and test the efficacy of existing antiepileptic drugs. Methods: SE was induced...
5.
Beske P, Hoffman K, Machamer J, Eisen M, McNutt P
Sci Rep
. 2017 Nov;
7(1):15862.
PMID: 29158500
Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay...
6.
Beske P, Bradford A, Hoffman K, Mason S, McNutt P
Toxicon
. 2017 Oct;
147:47-53.
PMID: 29054436
Botulinum neurotoxins (BoNTs) are exceedingly potent neurological poisons that block cholinergic release in the peripheral nervous system and cause death by asphyxiation. While post-exposure prophylaxis can effectively eliminate toxin in...
7.
Vazquez-Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al.
Sci Rep
. 2017 Feb;
7:42923.
PMID: 28220863
Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartments with exquisite specificity. While the native toxin is extremely lethal, bioengineering of BoNT has the potential to...
8.
Beske P, Bradford A, Grynovicki J, Glotfelty E, Hoffman K, Hubbard K, et al.
Toxicol Sci
. 2015 Nov;
149(2):503-15.
PMID: 26615023
Clinical manifestations of tetanus and botulism result from an intricate series of interactions between clostridial neurotoxins (CNTs) and nerve terminal proteins that ultimately cause proteolytic cleavage of SNARE (soluble N-ethylmaleimide-sensitive...
9.
Beske P, Scheeler S, Adler M, McNutt P
Front Cell Neurosci
. 2015 May;
9:159.
PMID: 25954159
Botulinum neurotoxins (BoNTs) are extremely potent toxins that specifically cleave SNARE proteins in peripheral synapses, preventing neurotransmitter release. Neuronal responses to BoNT intoxication are traditionally studied by quantifying SNARE protein...
10.
Beske P, Byrnes N, Astruc-Diaz F, Jackson D
J Neurochem
. 2014 Dec;
132(5):504-19.
PMID: 25475532
A hallmark of ischemic/reperfusion injury is a change in subunit composition of synaptic 2-amino-3-(3-hydroxy-5-methylisoazol-4-yl)propionic acid receptors (AMPARs). This change in AMPAR subunit composition leads to an increase in surface expression...