Philippe Mourrain
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Explore the profile of Philippe Mourrain including associated specialties, affiliations and a list of published articles.
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43
Citations
1758
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Recent Articles
11.
Mourrain P, Wang G
Curr Biol
. 2019 Jun;
29(12):R585-R588.
PMID: 31211981
A novel potential role of sleep is neuronal DNA repair. Live imaging of chromosome dynamics in zebrafish neurons has uncovered how sleep can repair DNA breaks accumulated during wake to...
12.
Andalman A, Burns V, Lovett-Barron M, Broxton M, Poole B, Yang S, et al.
Cell
. 2019 Apr;
177(4):970-985.e20.
PMID: 31031000
Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric...
13.
Leung L, Mourrain P
Curr Biol
. 2018 May;
28(9):R558-R560.
PMID: 29738730
Sleep durations vary greatly across animals from 2 to 20 hours with no clear explanation. A small Mexican cavefish reveals how the brain can adapt to increase its wake-stabilizing hypocretin...
14.
Madelaine R, Notwell J, Skariah G, Halluin C, Chen C, Bejerano G, et al.
Nucleic Acids Res
. 2018 Mar;
46(7):3517-3531.
PMID: 29518216
Thousands of human disease-associated single nucleotide polymorphisms (SNPs) lie in the non-coding genome, but only a handful have been demonstrated to affect gene expression and human biology. We computationally identified...
15.
Madelaine R, Mourrain P
Neural Regen Res
. 2017 Dec;
12(11):1765-1767.
PMID: 29239312
In humans, optic nerve injuries and associated neurodegenerative diseases are often followed by permanent vision loss. Consequently, an important challenge is to develop safe and effective methods to replace retinal...
16.
Madelaine R, Sloan S, Huber N, Notwell J, Leung L, Skariah G, et al.
Cell Rep
. 2017 Aug;
20(7):1533-1542.
PMID: 28813666
In the developing brain, neurons expressing VEGF-A and blood vessels grow in close apposition, but many of the molecular pathways regulating neuronal VEGF-A and neurovascular system development remain to be...
17.
Chiou S, Risca V, Wang G, Yang D, Gruner B, Kathiria A, et al.
Cancer Discov
. 2017 Aug;
7(10):1184-1199.
PMID: 28790031
Pancreatic ductal adenocarcinoma (PDAC) is one of the most metastatic and deadly cancers. Despite the clinical significance of metastatic spread, our understanding of molecular mechanisms that drive PDAC metastatic ability...
18.
Madelaine R, Lovett-Barron M, Halluin C, Andalman A, Liang J, Skariah G, et al.
Sci Rep
. 2017 Feb;
7:41528.
PMID: 28139691
RFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied the structural and functional...
19.
Wang G, Smith S, Mourrain P
Elife
. 2016 Nov;
5.
PMID: 27770568
The distribution of proteins within sub-synaptic compartments is an essential aspect of their neurological function. Current methodologies, such as electron microscopy (EM) and super-resolution imaging techniques, can provide the precise...
20.
Elbaz I, Zada D, Tovin A, Braun T, Lerer-Goldshtein T, Wang G, et al.
Mol Neurobiol
. 2016 Oct;
54(8):6581-6597.
PMID: 27734337
Sleep is tightly regulated by the circadian clock and homeostatic mechanisms. Although the sleep/wake cycle is known to be associated with structural and physiological synaptic changes that benefit the brain,...