Philippe Mourrain
Overview
Explore the profile of Philippe Mourrain including associated specialties, affiliations and a list of published articles.
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Articles
43
Citations
1758
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Recent Articles
1.
Qin W, Liang F, Lin S, Petree C, Huang K, Zhang Y, et al.
Nat Commun
. 2024 Jul;
15(1):5613.
PMID: 38965236
Advancements in CRISPR technology, particularly the development of base editors, revolutionize genetic variant research. When combined with model organisms like zebrafish, base editors significantly accelerate and refine in vivo analysis...
2.
Coulson R, Frattini V, Moyer C, Hodges J, Walter P, Mourrain P, et al.
iScience
. 2024 Mar;
27(4):109259.
PMID: 38510125
Fragile X syndrome (FXS) is caused by the loss of fragile X messenger ribonucleoprotein (FMRP), a translational regulator that binds the transcripts of proteins involved in synaptic function and plasticity....
3.
Coulson R, Mourrain P, Wang G
J Comp Physiol B
. 2024 Feb;
194(3):253-263.
PMID: 38396062
Individuals with neurodevelopmental disorders experience persistent sleep deficits, and there is increasing evidence that sleep dysregulation is an underlying cause, rather than merely an effect, of the synaptic and behavioral...
4.
Terzi A, Ngo K, Mourrain P
J Comp Physiol B
. 2024 Feb;
194(3):241-252.
PMID: 38324048
Sleep is an essential and evolutionarily conserved process that affects many biological functions that are also strongly regulated by cellular metabolism. The interdependence between sleep homeostasis and redox metabolism, in...
5.
Coulson R, Mourrain P, Wang G
Sleep Med Rev
. 2022 Apr;
63:101616.
PMID: 35381445
Neurological disorders encompass an extremely broad range of conditions, including those that present early in development and those that progress slowly or manifest with advanced age. Although these disorders have...
6.
Li S, Martinez Damonte V, Chen C, Wang G, Kebschull J, Yamaguchi H, et al.
Science
. 2022 Feb;
375(6583):eabh3021.
PMID: 35201886
Sleep quality declines with age; however, the underlying mechanisms remain elusive. We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive sleep fragmentation during aging. In aged mice, Hcrt neurons exhibited more...
7.
Jaggard J, Wang G, Mourrain P
Curr Opin Neurobiol
. 2021 Sep;
71:44-51.
PMID: 34583217
All animals carefully studied sleep, suggesting that sleep as a behavioral state exists in all animal life. Such evolutionary maintenance of an otherwise vulnerable period of environmental detachment suggests that...
8.
Madelaine R, Ngo K, Skariah G, Mourrain P
PLoS Genet
. 2020 Dec;
16(12):e1009244.
PMID: 33301440
The genetic origin of human skin pigmentation remains an open question in biology. Several skin disorders and diseases originate from mutations in conserved pigmentation genes, including albinism, vitiligo, and melanoma....
9.
10.
Leung L, Wang G, Madelaine R, Skariah G, Kawakami K, Deisseroth K, et al.
Nature
. 2019 Jul;
571(7764):198-204.
PMID: 31292557
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates....