Philippe Lenormand
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Explore the profile of Philippe Lenormand including associated specialties, affiliations and a list of published articles.
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17
Citations
1119
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Recent Articles
1.
Busca R, Onesto C, Egensperger M, Pouyssegur J, Pages G, Lenormand P
Nucleic Acids Res
. 2023 Jul;
51(15):7714-7735.
PMID: 37414542
We report the discovery of N-terminal alanine-rich sequences, which we term NTARs, that act in concert with their native 5'-untranslated regions to promote selection of the proper start codon. NTARs...
2.
Benzaquen J, Janho Dit Hreich S, Heeke S, Juhel T, Lalvee S, Bauwens S, et al.
Theranostics
. 2020 Oct;
10(24):10849-10860.
PMID: 33042257
The characterization of new theranostic biomarkers is crucial to improving the clinical outcome of patients with advanced lung cancer. Here, we aimed at characterizing the P2RX7 receptor, a positive modulator...
3.
Ndiaye P, Dufies M, Giuliano S, Douguet L, Grepin R, Durivault J, et al.
Theranostics
. 2019 Feb;
9(3):661-675.
PMID: 30809300
Hypoxic zones are common features of metastatic tumors. Due to inactivation of the von Hippel-Lindau gene (), renal cell carcinomas (RCC) show constitutive stabilization of the alpha subunit of the...
4.
Busca R, Pouyssegur J, Lenormand P
Front Cell Dev Biol
. 2016 Jul;
4:53.
PMID: 27376062
The MAP kinase signaling cascade Ras/Raf/MEK/ERK has been involved in a large variety of cellular and physiological processes that are crucial for life. Many pathological situations have been associated to...
5.
Busca R, Christen R, Lovern M, Clifford A, Yue J, Goss G, et al.
BMC Evol Biol
. 2015 Sep;
15:179.
PMID: 26336084
Background: The Ras/Raf/MEK/ERK signaling pathway is involved in essential cell processes and it is abnormally activated in ~30 % of cancers and cognitive disorders. Two ERK isoforms have been described,...
6.
Wolkenhauer O, Auffray C, Baltrusch S, Bluthgen N, Byrne H, Cascante M, et al.
Cancer Res
. 2009 Dec;
70(1):12-3.
PMID: 20028868
Systems biology takes an interdisciplinary approach to the systematic study of complex interactions in biological systems. This approach seeks to decipher the emergent behaviors of complex systems rather than focusing...
7.
Lidke D, Huang F, Post J, Rieger B, Wilsbacher J, Thomas J, et al.
J Biol Chem
. 2009 Nov;
285(5):3092-102.
PMID: 19920141
Upon activation, ERKs translocate from the cytoplasm to the nucleus. This process is required for the induction of many cellular responses, yet the molecular mechanisms that regulate ERK nuclear translocation...
8.
LeFloch R, Pouyssegur J, Lenormand P
Cell Cycle
. 2009 Feb;
8(5):705-11.
PMID: 19242111
Regulating ERK activity is essential for normal cell proliferation to occur. In mammals and most vertebrates ERK activity is provided by ERK1 and ERK2 that are highly similar, ubiquitously expressed...
9.
LeFloch R, Pouyssegur J, Lenormand P
Mol Cell Biol
. 2007 Oct;
28(1):511-27.
PMID: 17967895
The proteins ERK1 and ERK2 are highly similar, are ubiquitously expressed, and share activators and substrates; however, erk2 gene invalidation is lethal in mice, while erk1 inactivation is not. We...
10.
Antherieu S, Ledirac N, Luzy A, Lenormand P, Caron J, Rahmani R
J Cell Physiol
. 2007 May;
213(1):177-86.
PMID: 17503468
Endosulfan is an organochlorine insecticide described as a potential carcinogen in humans. This insecticide was recently reported to alter the mitogen-activated protein (MAP) kinase signaling pathways and is suspected to...