Philippe Barthe
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Explore the profile of Philippe Barthe including associated specialties, affiliations and a list of published articles.
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44
Citations
968
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Recent Articles
11.
Dubois C, Herrada I, Barthe P, Roumestand C
Molecules
. 2020 Dec;
25(23).
PMID: 33256081
High-hydrostatic pressure is an alternative perturbation method that can be used to destabilize globular proteins. Generally perfectly reversible, pressure exerts local effects on regions or domains of a protein containing...
12.
de Guillen K, Lorrain C, Tsan P, Barthe P, Petre B, Saveleva N, et al.
Sci Rep
. 2019 Dec;
9(1):18084.
PMID: 31792250
Rust fungi are plant pathogens that secrete an arsenal of effector proteins interfering with plant functions and promoting parasitic infection. Effectors are often species-specific, evolve rapidly, and display low sequence...
13.
Alqaseer K, Turapov O, Barthe P, Jagatia H, De Visch A, Roumestand C, et al.
Mol Microbiol
. 2019 Sep;
112(6):1847-1862.
PMID: 31562654
Mycobacterium tuberculosis (Mtb) is able to persist in the body through months of multi-drug therapy. Mycobacteria possess a wide range of regulatory proteins, including the protein kinase B (PknB) which...
14.
Saotome T, Doret M, Kulkarni M, Yang Y, Barthe P, Kuroda Y, et al.
Biomolecules
. 2019 Jul;
9(8).
PMID: 31357538
Dengue fever is a mosquito-borne endemic disease in tropical and subtropical regions, causing a significant public health problem in Southeast Asia. Domain III (ED3) of the viral envelope protein contains...
15.
Cordeiro T, Sibille N, Germain P, Barthe P, Boulahtouf A, Allemand F, et al.
Structure
. 2019 Jun;
27(8):1270-1285.e6.
PMID: 31178221
In its unliganded form, the retinoic acid receptor (RAR) in heterodimer with the retinoid X receptor (RXR) exerts a strong repressive activity facilitated by the recruitment of transcriptional corepressors in...
16.
Lesne J, Chang H, De Visch A, Paloni M, Barthe P, Guichou J, et al.
Sci Rep
. 2019 Feb;
9(1):1840.
PMID: 30755682
Chemically-induced dimerization (CID) systems are essential tools to interrogate and control biological systems. AcVHH is a single domain antibody homo-dimerizing upon caffeine binding. AcVHH has a strong potential for clinical...
17.
Turapov O, Forti F, Kadhim B, Ghisotti D, Sassine J, Straatman-Iwanowska A, et al.
Cell Rep
. 2018 Oct;
25(1):57-67.e5.
PMID: 30282038
Tuberculosis claims >1 million lives annually, and its causative agent Mycobacterium tuberculosis is a highly successful pathogen. Protein kinase B (PknB) is reported to be critical for mycobacterial growth. Here,...
18.
Herrada I, Barthe P, Vanheusden M, DeGuillen K, Mammri L, Delbecq S, et al.
Biophys J
. 2018 Jul;
115(2):341-352.
PMID: 30021109
A complete description of the pathways and mechanisms of protein folding requires a detailed structural and energetic characterization of the folding energy landscape. Simulations, when corroborated by experimental data yielding...
19.
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jager D, et al.
J Nucl Med
. 2018 Apr;
59(9):1423-1429.
PMID: 29626120
The tumor stroma, which accounts for a large part of the tumor mass, represents an attractive target for the delivery of diagnostic and therapeutic compounds. Here, the focus is notably...
20.
Barthe P, Veyron-Churlet R, De Visch A, Gilleron M, Saliou J, Tomavo S, et al.
Structure
. 2016 Aug;
24(10):1788-1794.
PMID: 27568926
Mycobacterium tuberculosis (Mtb) encodes several bacterial effectors impacting the colonization of phagocytes. LppM (Rv2171) is both implicated in phagocytosis and able to efficiently block phagosomal acidification in the macrophage, two...